BDgene

PBA Study Report

Basic Info
Reference Askland, K., 2009 PMID: 19052778
Citation Askland, K., C. Read, et al. (2009). "Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission." Hum Genet 125(1): 63-79.
Data Set WTCCC Bayesian genotypic
PBA Approach Fisher exact test
No. of Reported Pathways 142

Pathways reported by this study (count: 142)
Pathway Source Pathway ID Pathway Name in Paper Result Parameters Gene List
GO GO:0000155 GO: 0000155: two-component sensor act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function
GO GO:0003730 GO: 0003730: mRNA 3 -UTR binding Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function RBMS3 ELAVL2 RC3H1 HNRNPC
GO GO:0004114 GO: 0004114: 3',5';-cyclic-nucleotide phosphodiesterase act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function PDE4D PDE10A PDE4B
GO GO:0004222 GO: 0004222: metalloendopeptidase act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function THSD4 MMP3 LMLN ADAM12 MMP9 MMP16 ADAM18 TLL2
GO GO:0004289 GO: 0004289: subtilase act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function
GO GO:0004697 GO: 0004697: protein kinase C act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function PRKCE PRKCZ
GO GO:0004714 GO: 0004714: transmembrane receptor protein tyrosine kinase act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function EGFR ROR2 ROR1 NTRK3 ERBB4
GO GO:0004745 GO: 0004745: retinol dehydrogenase act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function
GO GO:0004872 GO: 0004872: receptor act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function EDA2R RTN4R NOTCH4 EDAR ATRNL1 SLC20A1 HTR3A MED12 SEC63 CMKLR1 SEMA3D ITGB8 PLA2R1 TLR4 CHRM3 GABRA5 NRXN3 NRXN1 CSF2RB
GO GO:0005001 GO: 0005001: transmembrane receptor protein tyrosine phosphatase act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function PTPRN2 PTPRO PTPRZ1 PTPRD PTPRE
GO GO:0005003 GO: 0005003: ephrin receptor act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function EPHA5
GO GO:0005158 GO: 0005158: insulin receptor binding Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function IGF1 PIK3R1 INS DOK5 SNX4
GO GO:0005159 GO: 0005159: insulin-like growth factor receptor binding Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function GNAS PIK3R1 IGF1 INS YWHAH
GO GO:0005198 GO: 0005198: structural molecule act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function NPHP4 LAMA3 DSP TUBA1B LAMB1 KRT3 VCL MAPK8IP2 BVES CLTC KRT75 SEMG2 CLDN16 ANXA1
GO GO:0005216 GO: 0005216: ion channel act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function HTR3B CHRNA1
GO GO:0005244 GO: 0005244: voltage-gated ion channel act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function KCNK10 KCNIP4
GO GO:0005245 GO: 0005245: voltage-gated Ca2+ channel act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function CACNA1D CACNB2 NALCN CACNA1E CACNA2D4 CACNA1B CACNG1 CACNA1S CACNA2D1 CACNG5 GRM7 CACNA1C CACNG2 CACNB3
GO GO:0005247 GO: 0005247: voltage-gated Cl- channel act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function
GO GO:0005249 GO: 0005249: voltage-gated K+ channel act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function KCND2 KCNH7 KCNQ2 KCNQ3 HTR3A
GO GO:0005251 GO: 0005251: delayed rectiWer K+ channel act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function KCNQ2 KCNQ3 KCND2
GO GO:0005254 GO: 0005254: Cl- channel act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function GABRG3 GABRB2 GABRB1 GABRA4 SLC1A4 GABRA3 GABRR1 GABRA6 GABRB3 GABRA1 GABRR3 GABRA5
GO GO:0005262 GO: 0005262: Ca2+ channel act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function GRIN3A CACNB2 CHRNA9 GRIN2A RYR2 GRIN2B CHRNA10 TRPM2 GRIN1
GO GO:0005267 GO: 0005267: K+ channel act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function KCNK10 KCNQ3 KCNQ2 KCNIP4
GO GO:0005509 GO: 0005509: Ca2+ ion binding Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function NCALD CDH7 PITPNM2 MMP3 PLA2G1B DST OC90 PON1 EPDR1 TLL2 GRIN1 ANXA1 CACNA1E CCBE1 FBN1 NCAN CDH13 LRP8 HSPA5 DGKB MYL12B CACNA1B ITIH1 PCDH15 MMP16 CAMKK2 NOTCH4 SVEP1 NOTCH3 CDHR3 FBLN2 HSP90B1 MYL12A FSTL4 GRM7 SLIT3 SRR PPP3CB RYR2 NRXN1 PLCG1 UMOD KCNIP4 FSTL5 PNLIPRP1 ATP2A2 S100B GCH1 CDH15 GUCA1A
GO GO:0005516 GO: 0005516: calmodulin binding Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function CAMK2A WFS1 GRIN1 RASGRF2 MYO5B RGS4 NRGN RYR2 GRM4 PCNT NOS3 NOS1 CACNA1C KCNN3 CAMKK2 PLA2G6 MYH14 PPP3CB PPP3CC VAMP2
GO GO:0005886 GO: 0005886: plasma membrane Results given for gene sets with P < 0.01 from the NIMH PBA-CC data ADRA1B CSF2RB GABRB3 APOB DIO3 GABRG3 ATP1A1 GRM2 ABCC11 ERBB4 VEPH1 PIK3R1 SSTR5 DSP DPP6 CAMK2A KCNMB2 ITGA9 P2RX7 OR5AS1 HCAR2 DRP2 TSHR VCL CHRM2 CHRNA3 SLC39A3 SLC6A2 GAD1 ADRA2C TRPM2 HCAR3 HTR1F GNAZ SSTR1 CHRNB4 HTR3B SLC14A1 ADRB2 MC5R SNAP29 ADCY2 OPCML LRRFIP1 GSK3B BDKRB1 CDHR3 DCC MCHR1 NRXN1 ANXA1 TAS1R3 GABRA4 CSMD3 RGS4 CMKLR1 MUC16 GRIA3 SCN7A PSKH1 ZAN CAP2 TFRC DRD2 CIT MTNR1A SLC9A3 MBP BVES DLG1 CACNA1B HSPA5 PLXNA2 ACE COBL DRD1 CHRNA6 SNAP25 OR2Y1 GNAL GABRB2 PILRA HSP90B1 FLVCR2 OR3A1 EVA1A P2RX4 RASGRF2 GRIN2A OR1B1 RTN4R PPP3CB TNK2 CHRM3 GJA1 COMT TNF CHRNB3 SLC6A3 SEMA5A NPFFR2 HTR5A TAAR1 ANO3 CADM2 PRKCE FGFR2 HCRTR2 GPR124 ROR2 GABRA5 ADORA2B GNB3 CD36 NMUR2 TENM2 PRKACB HTR3A SLC15A1 PTPRT CHRNA2 TLR4 MARCH1 GRIK5 AQP8 PTPRE SLC1A4 MDGA1 EGFR ALG10B NUMB CHRNA9 DLG2 OR4X2 MLC1 PALLD NTSR2 CNNM4 CCKBR HTR6 CNTN4 RAC1 PARVB GNA12 NOTCH4 DGKQ EXOC4 DGKH SERINC1 MALL GABRR1 P2RY13 CHL1 CDV3 FYN VAMP3 THSD7A CRIM1 LEPR ITGB8 GRM4 EPHA5 GABBR2 IL1RN DIO2 ABCG1 DRD5 CNR2 CACNA1E SLCO3A1 HTR2A GRIN2B HLA-G SLC12A6 ATP6V1G1 RGS7 GRIK2 SLC2A9 GABRA1 PLCG1 CDC42BPB GRM7 ADRA1A SNCG HTR1A GABRA6 PROKR2 CHRNA5 SRR YWHAH LMBR1L AKAP10 SLC22A16 AGTR1 ROR1 GRIK4 CYTH4 GLDN KNTC1 FAM84B KCNN3 HCRTR1 VAMP2 PTPRO VAMP7 ATP1A3 SCN8A GPR78 SLC6A4 GRIP1 GNAS HTR4 HLA-B PTGFR CAPN10 PIK3C2A GPC5 DIRAS2 FZD2 TCAF1 IGF1 PIK3CG CHD1L SHANK2 CHRNA1 GLRA1 MCHR2 PLA2R1 SLC20A1 CSNK2A1 UPK3B KCNIP4 PCDH15 ARRB2 CHRM1 CLDN16 TAB2 OXTR EDAR ANK2 CSNK1D HTR7 APOE MAGI2 CDH15 BASP1 PRLR SLC18A2 ATP6V1H AKT1 PI4KA MARCO ADCY8 CRHR1 GUCA1A TACR1 SLC1A1 ATP1B3 HTR1D CHRNB2 TRPC4AP FZD3 GRM3 NOS3 NALCN FGFRL1 KCNH7 GFRA1 WWOX MAPK10 CRHR2 DRD4 SLC30A8 HLA-A LRP8 BDKRB2 CACNA1D HTR1E TRH ADRA2A NPTX1 RTN4 LIMS2 PLCG2 CHRM5 GRIN1 GRIK3 CACNA1S GNAI2 DPP10 MAGI1 PICK1 ITGB6 KMT2E SVIL CDH7 SERPINA12 IL2RB VAPA DGKB SLC1A2 NOTCH3 CHRNA4 GABRR3 ATP1A2 PARD6B ZHX2 ESR1 RGS17 RGS5 ABCB1 SLC6A5 GAD2 MMP16 LRBA FEZ1 PAWR VIPR2 ATP6V0A2 TRHR KCNQ3 SNX4 SGCG JAM3 PRKAR1A CHRM4 ANK3 KCND2 ADCY9 DRD3 CLTC DLG3 NCAM1 GRIA1 RGMA CTLA4 CHRNA7 HTR2C GRIN2D ADAM12 GABRA3 PRKCZ SLC17A3 PARVG KCNQ2 RYR2 CNR1 ANO2 GABRB1 PIP4K2A ANKS4B CDH13 CNTN6 CACNG2 DSCAM CACNA1C KCNK10 HSP90AA1 AVPR1B PALM3
GO GO:0005887 GO: 0005887: integral to plasma membrane Results given for gene sets with P < 0.01 from the NIMH PBA-CC data ADRA2A TAAR6 HTR1F PTPRN2 GRIN2A ATP2A2 EDA2R GRIK4 CMKLR1 P2RX4 FGFR2 SIGLEC6 GABRB2 GABBR2 DRD3 TENM2 STEAP3 ADORA2B VAMP2 NPFFR2 SLC2A9 CSF2RB NRG3 ABCA13 BDKRB2 SLC18A2 TFRC SLC6A3 DRD4 GRIK2 CHRM3 GABRA3 CHRNB4 ABCC11 HLA-B ADRA2C PTPRO CCKBR CHRM5 HTR3B HTR1E TRHR VIPR2 CHRM1 NRXN1 HTR5A P2RX7 MCHR1 AQP8 TNF HTR4 GABRB1 GRM4 PLA2R1 ABCG1 CACNB2 CHRM4 TAAR1 HTR1A TRPM2 HCAR3 SLC6A2 HTR1D SLC17A3 DRD5 TENM4 TAAR8 CRHR1 OR5AS1 NUMB SLC15A1 ADCY9 DSCAM HTR2C SYPL1 MC5R SLC12A6 ADRA1B CD36 GABRA6 SLC14A1 NRXN3 DRD1 GRM7 AVPR1B OXTR KCND2 FAM26F CHRM2 ROR2 GJA5 P2RY13 PLXNA2 TACR1 SLC20A1 HLA-A CNR1 CHRNB1 GRM3 TM9SF2 CTLA4 HCRTR2 GABRA1 DRD2 ROR1 ANK2 NTRK2 HTR3A PTPRD MMP16 NRG1 GRIN2B GLRA1 MTNR1A SLC1A1 GRIK3 KCNK10 SLC4A11 ADRB2 PTGFR IL17RA GPC5 HTR6 GABRB3 MARCO CRHR2 SSTR5 TSHR AGTR1 GABRA5 GABRR1 GRIN1 GJA8 CHRNA9 NOTCH4 CNR2 SLC6A4 IL2RB GRM2 GJA1 TLR4 GPR87 KCNH7 HTR2A PTPRZ1 SLC1A4 KCNMB2 EPHA5 NTSR2 GABRA4 GPR50 HCRTR1 SSTR1 BDKRB1 MUC4 NTRK3 ADRA1A HTR7
GO GO:0005891 GO: 0005891: voltage-gated Ca2+ channel complex Results given for gene sets with P < 0.01 from the NIMH PBA-CC data CACNG2 CACNA1E CACNB3 CACNA2D4 CACNA1S CACNA1D PDE4B CACNA1B CACNG1 CACNA1C PDE4D CACNA2D1 CACNB2
GO GO:0006811 GO: 0006811: ion transport Results given for gene sets with P < 0.01 from the NIMH PBA-BP data SLC22A23 CHRNA2 CHRNB2 SLC1A1 MLC1 SLC9A3 SLC1A2 CHRNA4 GLRA1 CNNM4 SLC20A1 CHRNB4 CHRNA3 SLC15A1 GABRB1 SLC1A4 CHRNA7 SLC12A6
GO GO:0006813 GO: 0006813: K+ ion transport Results given for gene sets with P < 0.01 from the NIMH PBA-BP data ATP1A2 GJA5 KCNQ3 SLC12A6 KCNQ2 KCNMB2
GO GO:0006816 GO: 0006816: Ca2+ ion transport Results given for gene sets with P < 0.01 from the NIMH PBA-BP data GRIN3A CHRNB2 CAMK2A FYN NMUR2 CHRNA7 TRPM2 P2RX4 CACNA2D1 RYR2 CACNA1S CACNB3 CHRNA4 CACNA1D
GO GO:0007155 GO: 0007155: cell adhesion Results given for gene sets with P < 0.01 from the NIMH PBA-BP data DSCAM KIAA1462 CHL1 LAMA3 TNR SVEP1 MAGI1 COL28A1 CADM2 IGFBP7 ITGB8 DST SEMA5A ATP2A2 RELN RAC1 HES1 OPCML CXCL12 LAMB1 FEZ1 ITGA9 CTNND2 MUC16 PRKCE VCL CNTNAP5 CCL2 CD36 CNTN6 ITGB6 SIGLEC6 NCAN LMLN CDH15 NCAM1 DGCR6 PTPRT ADAM12 PARVB ACAN SDK1
GO GO:0007194 GO: 0007194: negative regulation of adenylate cyclase act. Results given for gene sets with P < 0.01 from the NIMH PBA-BP data GRM3 GRM7 GNAI2 GABBR2 GPR87 DRD4 DRD3 P2RY13 GRM2 ADRA2A DRD2
GO GO:0007268 GO: 0007268: synaptic transmission Results given for gene sets with P < 0.01 from the NIMH PBA-BP data DRD4 NRXN3 CHRNA1 GAD1 GABRA6 CAMK2A NPTX1 GABRA5 SLC6A3 GABRB2 GABRG3 HTR3A CACNA1B ADCY9 CHRNA4 NRXN2 DRD3 HTR6 CRH NCALD RASGRF2 CHRNB2 CACNB3 PMCH GRIK3 DBH HTR2A GAD2 SST SNCG CHRNB4 GRIN1 GRIN2D KCNQ3 CHAT GRIK2 SYN2 GNAL SLC6A2 COMT GABRB1 NRXN1 PPFIA1 HTR1D CHRNA3 CACNA1E GRIA1 ALDH2 CREB1 GNAI2 GABBR2 CACNB2 KCND2 NEFL CHRNB3 DLG1 GRM2 SYPL1 DLG2 FGF12 PICK1 KCNK10 PRKACB SNAP25 GABRR3 HCRTR2 GABRA1 GRIN2A MBP HTR1E KCNH7 KCNN3 GRIP1 VAMP2 CHRNA6 CHRNA7 GRM7 GRIK4 GNB3 SLC6A5 DLG3 CARTPT NPFFR2 GABRA3 SLC1A1 CACNG2 GRM3 GABRB3 PNOC HCRTR1 HTR2C HTR3B KCNQ2 DRD5 GRIA3 SLC1A2 ADCY2 GRIN2B CHRNA9 CHRNA2 HTR7 SSTR5 KCNMB2 ADCY8 MAOA HTR1F TSPO GRIK5 GABRA4 CHRNA5 GABRR1 CACNA1C GRM4 SSTR1 HTR4 SLC18A2
GO GO:0007275 GO: 0007275: multicellular organismal development Results given for gene sets with P < 0.01 from the NIMH PBA-BP data ZNF74 TSNAX LEPR TLL2 SLC22A16 CREM ADRA1B FAM3C MEOX2 CDK13 EBF1 ATRNL1 CTNND2 UTP14C SPRED1 IFRD1 MOV10L1 TDRD9 PMCH ADAM18 ROR2 GNRH1 EDA2R ITGB6
GO GO:0007399 GO: 0007399: nervous system development Results given for gene sets with P < 0.01 from the NIMH PBA-BP data FEZ1 BDNF DOK5 DLG3 DGCR14 FABP7 DPYSL2 DLG2 CHRM1 TSHR NRGN TPP1 FGF12 PPP2R5D DSCAM GDNF CHRM2 SEMA3D CNTN4 APOB CHRNA3 MYT1L NDUFV2 CRIM1 DLG1 LGI1 ARID1B KCNQ2 ERBB4 SCN8A SEMA5A HES1 MTR NR2E1 CHRM3 OLFM1 NRG1 GSS ST8SIA2 MBNL1
GO GO:0007411 GO: 0007411: axon guidance Results given for gene sets with P < 0.01 from the NIMH PBA-BP data LGI1 TRIO CAP2 CACNA1C EPHA5 CACNB2 KIF5B CHL1 ROBO2 KCNQ2 RELN GFRA1 CACNB3 MYL12B GLI3 DLG1 NCAM1 NUMB CNTN4 GDNF TNR FEZ1 CREB1 OTX2 PLXNA2 DCC PLCG1 CACNA1D KCNQ3 CSNK2A1 LAMB1 BDNF SEMA5A NRXN3 GRIN2B CNTN6 MYL12A ST8SIA2 NRXN1 SLIT3 TENM2 MMP9 FYN CACNA1S NCAN NCK2 MYH14 EGFR HSP90AA1 ANK2 DLG3 DPYSL2 GRIN1 GLI2 RAC1 RGMA ITGA9 ANK3 GSK3B PTPRO
GO GO:0007417 GO: 0007417: central nervous system development Results given for gene sets with P < 0.01 from the NIMH PBA-BP data FYN SNTG2 RELN NMUR2 ARNT2 DRP2 GABRA4 S100B TPP1 PARK2 GPR124 PAX8 POU6F2 ROBO2 MBP NPAS2 NPTX1 XRCC4 NCAN CNTN6 PTPRZ1
GO GO:0007420 GO: 0007420: brain development Results given for gene sets with P < 0.01 from the NIMH PBA-BP data GABRA5 BDH1 APOD ZIC2 ATP6V0D1 SRR NIPBL MDGA1 BCL2L11 BCR OXCT1 MACROD2 BRCA2 NME7 ARRB2 ARNT2 EGR2 CNTN4 NF1 PHF8 CADM2 TCF7L2 RELN TCF7L1 ROBO2
GO GO:0008076 GO: 0008076: voltage-gated K+ channel complex Results given for gene sets with P < 0.01 from the NIMH PBA-CC data KCNIP4 CTTN KCNQ2 KCND2 KCNMB2 DLG2 DPP6 KCNQ3
GO GO:0008092 GO: 0008092: cytoskeletal protein binding Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function CAPN10 FABP3 ANK3 DLG1 FARP1 FRMD3
GO GO:0008146 GO: 0008146: sulfotransferase act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function
GO GO:0008188 GO: 0008188: neuropeptide receptor act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function HCRTR1 SORCS2 NPFFR2 MCHR1 HCRTR2
GO GO:0008237 GO: 0008237: metallopeptidase act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function RNPEPL1 MMP9 ACE ADAMTSL1 ADAMTSL3 ADAM18 ADAM12 NAALAD2
GO GO:0008536 GO: 0008536: Ran GTPase binding Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function
GO GO:0009411 GO: 0009411: response to UV Results given for gene sets with P < 0.01 from the NIMH PBA-BP data ERCC4 RAD18 TIPIN
GO GO:0015085 GO: 0015085: Ca2+ ion transmembrane transporter act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function
GO GO:0015269 GO: 0015269: Ca2+-activated K+ channel act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function KCNMB2
GO GO:0016020 GO: 0016020: membrane Results given for gene sets with P < 0.01 from the NIMH PBA-CC data SEMA3D IL2RB ST3GAL1 SVEP1 STK24 SORCS2 SLC15A1 DPYSL2 ADAM18 SEC63 DSCAM HNRNPC CD36 GNL3 MYH14 CRBN ALOX12 PDLIM5 TFRC APOE ESR1 ADCY2 CHRNA10 NCAPD3 MED15 PI4K2B YWHAE GRIN3A PLD1 GFAP HSP90AA1 MED12 RBM23 COBL CHRM1 CHN2 NR3C1 TOM1 TPST2 PIK3C2A EXOC4 PDE4D ZDHHC13 CIT LRP8 PIK3CG MTMR3 RAC1 PRKAR1A BCR LRBA CLTC NUP107 SNX4 NDE1 DDX55 SLC1A2 LMLN GNAS HPS4 OPA1 SEMA5A NCAM1 NPHP4 PREP SLC1A4 MUC4 PLEKHA5 SLC20A1 NUF2 SNAP25 RYR2 HLA-G DAB1 DPP10 MTOR FGFR2 NCOR2 KIF5B TIAM2 HSP90B1 ABCB1 BET1 ATP6V0D1 MsrA PLA2G6 P2RX7 ADCY8 BCL2 COMT DOCK9 SIGLEC6 EGFR SLC6A2 PRKCZ LSG1 GLI2 HLA-B HTR4 P2RX4 CHRNA4 PCNT CACNB3 OSBP2 DIO2 DBH ARHGAP15 PTRH2 ATP2A2 NF1 NRG1 RUVBL2 HSPA5 ASAP1 DRD4 GNAI2 DLG2 SLC18A2 SLU7 ATP1A1 SLC1A1 VAMP2 GLT8D1 DYNC1H1 ALG9 PIK3R1 PI4KA HLA-A FOXO3 PIK3C3 DPY19L1 TNK2 VAMP7 DDX18 FKBP5 MTHFD1 ACAP2
GO GO:0016021 GO: 0016021: integral to membrane Results given for gene sets with P < 0.01 from the NIMH PBA-CC data EXTL1 NDST3 GLDN SEL1L2 MAOA ITPRIPL2 DPY19L1 MARCH1 SLC39A3 RNF144B ANO3 MPC2 TSPAN8 ESR1 PILRA ACE SYNE1 TMEM151B ATRNL1 GRM7 SEMA5A MPPE1 TBXAS1 CHRNB2 KCNQ3 TSPO MCHR2 ZDHHC19 SRD5A2 GRIN3A PCDH15 NRXN1 ATP1A1 STX12 SPTLC1 MALL COX10 NMUR2 OR4X2 THSD7A ADAM18 LEPR PLD5 COMT TMEM217 VAMP3 ATP1A3 B3GALT5 TMEM132E CACNA1C CSMD1 ADCY8 PTPRT DNAJC16 OR2Y1 EVC FZD2 SLC12A6 FMO5 CMKLR1 PVRIG SLC1A4 NALCN TMEM108 SEC63 CHL1 NRXN2 VAPA FAM20B NCAM1 SYNGR1 ABCC12 DIO3 EVA1A KHDC1 DIO2 FGFR2 BET1 SLC9A3 PTPRO PRLR SLC18A1 SLCO3A1 ASTN2 GPR78 THSD7B SCN8A SRD5A1 SLC6A3 OR3A1 GLRA1 FGFRL1 KCNN3 SLC5A12 POPDC3 GALNT13 FAAH GGTA1P OPA1 FRMD3 TAOK2 XKR4 HS6ST2 SLC22A23 PROKR2 ARV1 PTPRE CHRNA7 ALG10B MFSD11 ABHD2 KCND2 ZAN ADAM12 EDAR SERINC1 LRBA SGCZ CNTNAP5 NAALAD2 NOTCH3 HCAR2 FZD3 LHFPL3 CHRNB3 SLC2A9 DPY19L3 VKORC1L1 NRXN3 ATP13A4 LINGO2 MLC1 CNNM4 TMEM222 CLDN16 FAR2 PLA2R1 SDK1 LMAN2L PITPNM2 GLT8D1 CDHR3 PCSK5 DPP10 CADM2 CHRNA2 AGTR1 HLA-B TPST2 TAAR6 LRP8 MGAT4A SLC1A2 SLC30A8 ASTN1 SLC25A21 ZDHHC13 GPR124 CDH7 JAM3 SMCO1 BVES CRIM1 B3GALT1 ATP6V0A2 VAMP7 LRRC15 SGCG CD276 IMMP2L XBP1 TAS1R3 DBH ROBO2 DPP6 ALG9 MAOB LMBR1L ZDHHC8 CSMD3 DST FLVCR2 CMTM8 HEPACAM2 SEZ6L PRSS55 ABCB1 CHRNB4 SORCS2 CHRFAM7A CDH15 SLC6A5 IL15RA CHRNA4 FER1L6 XXYLT1 OR1B1 CHRNA3 POMGNT2 CRHR1 SYPL1 ERBB4 EGFR TYR DPCR1 EDA2R VRK2 ADCY2 TAAR1 TAAR8 LAMP3 SLC22A16 CERS3 TM4SF19 KCNQ2 MUC16 UPK3B DCC HS3ST4
GO GO:0016043 GO: 0016043: cellular component organization and biogenesis Results given for gene sets with P < 0.01 from the NIMH PBA-BP data
GO GO:0017048 GO: 0017048: Rho GTPase binding Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function DIAPH1 CDC42BPB DOCK9 CIT
GO GO:0019904 GO: 0019904: protein domain speciWc binding Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function DDC TACC3 MTOR NEFL TH BASP1 DRD3 ST13 CHMP1B YWHAE NDE1 PRKCZ HSPA5 IL1B GABRR3 TGM2 PICK1 VAPA MED12 TACC2 ATP1A1 YWHAH THRA ARRB2
GO GO:0019992 GO: 0019992: diacylglycerol binding Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function
GO GO:0030154 GO: 0030154: cell diVerentiation Results given for gene sets with P < 0.01 from the NIMH PBA-BP data INHBB NR1D1 ROR2 SRD5A1 YY1 GNA12 BHLHE41 ELK3 EDAR TDRD9 AKT1 PMCH TLL2 SEMA3D TSNAX THSD7A SRD5A2 JAK1 EDARADD NXN SLC22A16 FYN UTP14C CREM MYT1L NOTCH4 TNK2 PPARD INA ADAM18 DUSP6
GO GO:0030165 GO: 0030165: PDZ domain binding Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function GRIK5 EXOC4 GJA1 SNTG2 FZD3 CRIM1 GRM7 SLC9A3 PARK2 FZD2 GRIK2 GRIA1 LNX1 SRR CIT DLG3
GO GO:0030414 GO: 0030414: protease inhibitor act. Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function
GO GO:0030553 GO: 0030553: cGMP binding Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function PDE10A
GO GO:0030890 GO: 0030890: positive regulation of B cell proliferation Results given for gene sets with P < 0.01 from the NIMH PBA-BP data BCL2 TLR4 CHRNB2
GO GO:0030955 GO: 0030955: K+ ion binding Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function ATP1A1
GO GO:0031012 GO: 0031012: extracellular matrix Results given for gene sets with P < 0.01 from the NIMH PBA-CC data IGFBP7 CMA1 APOE FGFR2 FBLN2 FBN1 ACAN HSP90B1 LAMB1
GO GO:0031404 GO: 0031404: chloride ion binding Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function ACE
GO GO:0045202 GO: 0045202: synapse Results given for gene sets with P < 0.01 from the NIMH PBA-CC data CHRM3 SYN2 VAMP2 LGI1 CHRNB1 CADM2 FARP1 NOS1 GRIN1 ATP1A3 OLFM1 CCL2 CTBP2 CHRM4 MAGI2 TENM2 OLFM3 PICK1 PCDH15 PPP1R9A CHRM5 GRIN3A CHRM1 ADRA2A SNAP29 CHRM2 ATP1A2 SHISA9 VAMP7
GO GO:0045211 GO: 0045211: postsynaptic membrane Results given for gene sets with P < 0.01 from the NIMH PBA-CC data CHRNA6 DLG2 CHRM5 CHRNB4 GRIK5 GABRA5 GRIA3 GRIN2B PDLIM5 GABRB3 DISC1 KCND2 CHRNA3 ARRB2 BCR CPEB1 HTR3A CHRNB3 GRIN3A GRM7 CHRNA5 DLG1 GABRB2 GABRA6 CACNG5 CHRNB2 CHRNA9 CHRNA2 GRIA1 GABRR3 GRIK2 GRM3 TENM2 SYNE1 CHRM1 GABRR1 GABBR2 ANK3 SHANK2 GRIN2D GABRA3 CHRNA1 GRIP1 GRIK3 CHRNB1 GRID1 CHRM2 GABRB1 COMT GLRA1 GABRA4 GRIN2A CHRNA10 CHRNA7 DLG3 ANK2 GRIN1 CHRM3 PICK1 GABRA1 GABRG3 CHRM4 GRIK4 NTRK2 HTR3B KCTD12 DTNBP1 CHRNA4
GO GO:0050998 GO: 0050998: nitric-oxide synthase binding Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function SLC6A4
GO GO:0051015 GO: 0051015: actin Wlament binding Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function SYNE1 PICK1 MYH14 SVIL PPP1R9A CTNNA3 ADSSL1 SLC6A4 EGFR
GenMAPP pathways Pathway:WP1991 GenMAPP pathways: Smooth muscle contraction Results given for gene sets with P < 0.05 from NIMH PBA-Biopathways data
GenMAPP pathways Pathway:WP35 GenMAPP pathways: G Protein Signaling Results given for gene sets with P < 0.05 from NIMH PBA-Biopathways data
GenMAPP pathways Pathway:WP501 GenMAPP pathways: GPCRDB Class C Metabotropic glutamate pheromone Results given for gene sets with P < 0.05 from NIMH PBA-Biopathways data
GenMAPP pathways Pathway:WP536 GenMAPP pathways: Ca2+ regulation in cardiac cells Results given for gene sets with P < 0.05 from NIMH PBA-Biopathways data
GenMAPP pathways Pathway:WP98 GenMAPP pathways: Prostaglandin synthesis regulation Results given for gene sets with P < 0.05 from NIMH PBA-Biopathways data
GO GO:0003700 GO: 0003700: transcription factor act. P < 0.05 from the WTCCC PBAs NR3C1 NPAS2 YY1 ZKSCAN4 ZSCAN31 PAX8 MYT1L HES1 POU6F2 ZNF490 ZHX2 EGR1 CREB1 ID1 RORA GLI2 XBP1 FOXN3 TCF4 ZNF274 AHR RNF4 ZIC2 TBP AFF1 PPARD TEAD1 NFIL3 ZXDC ATF4 POU3F2 MKL2 HOXA3 CREBBP HMG20A TCF7L2 CSRNP2 ARNT2 EGR4 ARNTL2 ESR1 FOXO3 MEOX2 RORB TFAM ZNF74 NFIX FOXP2 RFX4 EBF1 TULP4 CREM HSF2 NR3C2 TCF7L1 CLOCK EGR3 THRA TFAP2B GSC2 ELK3 HNF4A NFIA EGR2 GLI3 IRF2
GO GO:0003707 GO: 0003707: steroid hormone receptor act. P < 0.05 from the WTCCC PBAs RORA NR2E1 HNF4A NR4A2 NR1D1 NR3C2 ESR1 THRA RORB PPARD
GO GO:0003714 GO: 0003714: transcription corepressor act. P < 0.05 from the WTCCC PBAs ZHX2 SIRT1 TFAP2B KCTD1 BHLHE41 JAZF1 HDAC9 BASP1 TLE4 CTBP2 NR1D1 ZNF274 BCL11A NCOR2 NRIP1 AEBP2 NFIL3 PAWR ELK3 ATF5 YY1
GO GO:0003774 GO: 0003774: motor act. P < 0.05 from the WTCCC PBAs MYO18B DYNC1I1
GO GO:0003779 GO: 0003779: actin binding P < 0.05 from the WTCCC PBAs KLHL20 YWHAH ACE PAWR MKL2 XIRP2 MYO18B PARVG WDR1 NCALD INO80 PARVB PARK2 VCL SNTG2 DIAPH1 PALLD MYO5B PDLIM5 WIPF1 CAP2 SYNE1 ACTR3B DST
GO GO:0004065 GO: 0004065: arylsulfatase act. P < 0.05 from the WTCCC PBAs
GO GO:0004114 GO: 0004114: 3',5';-cyclic-nucleotide phosphodiesterase act. P < 0.05 from the WTCCC PBAs PDE4D PDE10A PDE4B
GO GO:0004222 GO: 0004222: metalloendopeptidase act. P < 0.05 from the WTCCC PBAs THSD4 MMP3 LMLN ADAM12 MMP9 MMP16 ADAM18 TLL2
GO GO:0004553 GO: 0004553: hydrolase act., hydrolyzing O-glycosyl compounds P < 0.05 from the WTCCC PBAs GBE1
GO GO:0004871 GO: 0004871: signal transducer act. P < 0.05 from the WTCCC PBAs PLCL2 RGS7 NPAS3 PER1 PLCXD3 MAGI2 GJA1 GNA12 PPFIA1 ARNTL2 GNB3 CREBBP IL15RA CLOCK ARNTL PRKCE SLC20A1 PER3 GNAZ KCNH7 GNAL GNAS FST AHRR NPAS2 PLCG2 AHR VAPA ARNT2 ZDHHC13 GNAI2 PER2
GO GO:0004872 GO: 0004872: receptor act. P < 0.05 from the WTCCC PBAs EDA2R RTN4R NOTCH4 EDAR ATRNL1 SLC20A1 HTR3A MED12 SEC63 CMKLR1 SEMA3D ITGB8 PLA2R1 TLR4 CHRM3 GABRA5 NRXN3 NRXN1 CSF2RB
GO GO:0004879 GO: 0004879: ligand-dependent nuclear receptor act. P < 0.05 from the WTCCC PBAs NR1D1 RORB RORA NR4A2 AHR PPARD HNF4A
GO GO:0004890 GO: 0004890: GABA-A receptor act. P < 0.05 from the WTCCC PBAs GABRA6 GABRR1 GABRA1 GABRB2 GABRA4 GABRA5 GABRB1 GABRB3 GABRG3 GABRA3 GABRR3
GO GO:0004970 GO: 0004970: ionotropic glutamate receptor act. P < 0.05 from the WTCCC PBAs GRID1 GRIK3
GO GO:0005001 GO: 0005001: transmembrane receptor protein tyrosine phosphatase act. P < 0.05 from the WTCCC PBAs PTPRN2 PTPRO PTPRZ1 PTPRD PTPRE
GO GO:0005003 GO: 0005003: ephrin receptor act. P < 0.05 from the WTCCC PBAs EPHA5
GO GO:0005085 GO: 0005085: guanyl-nucleotide exchange factor act. P < 0.05 from the WTCCC PBAs TIAM2 DOCK3 TRIO
GO GO:0005216 GO: 0005216: ion channel act. P < 0.05 from the WTCCC PBAs HTR3B CHRNA1
GO GO:0005234 GO: 0005234: extracellular-glutamate-gated ion channel act. P < 0.05 from the WTCCC PBAs GRID1 GRIK3 GRIN2A GRIK2 GRIN2D GRIN1 GRIN3A GRIK5 GRIA1 GRIK4 GRIN2B GRIA3
GO GO:0005244 GO: 0005244: voltage-gated ion channel act. P < 0.05 from the WTCCC PBAs KCNK10 KCNIP4
GO GO:0005249 GO: 0005249: voltage-gated K+ channel act. P < 0.05 from the WTCCC PBAs KCND2 KCNH7 KCNQ2 KCNQ3 HTR3A
GO GO:0005261 GO: 0005261: cation channel act. P < 0.05 from the WTCCC PBAs FAM26F
GO GO:0005262 GO: 0005262: Ca2+ channel act. P < 0.05 from the WTCCC PBAs GRIN3A CACNB2 CHRNA9 GRIN2A RYR2 GRIN2B CHRNA10 TRPM2 GRIN1
GO GO:0005267 GO: 0005267: K+ channel act. P < 0.05 from the WTCCC PBAs KCNK10 KCNQ3 KCNQ2 KCNIP4
GO GO:0005509 GO: 0005509: Ca2+ ion binding P < 0.05 from the WTCCC PBAs NCALD CDH7 PITPNM2 MMP3 PLA2G1B DST OC90 PON1 EPDR1 TLL2 GRIN1 ANXA1 CACNA1E CCBE1 FBN1 NCAN CDH13 LRP8 HSPA5 DGKB MYL12B CACNA1B ITIH1 PCDH15 MMP16 CAMKK2 NOTCH4 SVEP1 NOTCH3 CDHR3 FBLN2 HSP90B1 MYL12A FSTL4 GRM7 SLIT3 SRR PPP3CB RYR2 NRXN1 PLCG1 UMOD KCNIP4 FSTL5 PNLIPRP1 ATP2A2 S100B GCH1 CDH15 GUCA1A
GO GO:0008188 GO: 0008188: neuropeptide receptor act. P < 0.05 from the WTCCC PBAs HCRTR1 SORCS2 NPFFR2 MCHR1 HCRTR2
GO GO:0015085 GO: 0015085: Ca2+ ion transmembrane transporter act. P < 0.05 from the WTCCC PBAs
GO GO:0019992 GO: 0019992: diacylglycerol binding P < 0.05 from the WTCCC PBAs
GO GO:0030955 GO: 0030955: K+ ion binding P < 0.05 from the WTCCC PBAs ATP1A1
GO GO:0043565 GO: 0043565: sequence-speciWc DNA binding P < 0.05 from the WTCCC PBAs GLI2 TCF7L1 TFAP2B POU3F2 NR2E1 NR3C2 HES1 FOXO3 MEOX2 CUX2 TCF7L2 CLOCK PPARD THRA TRIM24 RORA ATF4 BCL2 AHR TSNAX GSC2 FOXP2 RORB CSRNP2 FOXN3 ARNTL ZNF274 EGR1 HOXA3
GO GO:0045296 GO: 0045296: cadherin binding P < 0.05 from the WTCCC PBAs NUMB CTNNA3 ANK3 P2RX4 PTPRT VCL CDH13
GO GO:0048037 GO: 0048037: cofactor binding P < 0.05 from the WTCCC PBAs WWOX DDO DAO
GO GO:0003707 GO: 0003707: steroid hormone receptor act. P < 0.05 from the WTCCC PBAs RORA NR2E1 HNF4A NR4A2 NR1D1 NR3C2 ESR1 THRA RORB PPARD
GO GO:0004653 GO: 0004653: polypeptide N-acetylgalactosaminyltransferase act. P < 0.05 from the WTCCC PBAs GALNT13
GO GO:0004672 GO: 0004672: protein kinase act. P < 0.05 from the WTCCC PBAs TRIM24 ADRBK2 PIK3C3 CDK13 AKT1 CSNK1D STK24 PRKCZ CCL2 CDC42BPB CSNK1E TRIB1 PIK3CG
GO GO:0004674 GO: 0004674: protein serine/threonine kinase act. P < 0.05 from the WTCCC PBAs STK39 NEK5 CSNK1E EIF2AK4 STK24 BCR PIK3CG SLK CAMK2A CSNK1D CSNK2A1 PRKCE NEK4 NEK7 TNK2 CIT PRKCZ AKT1 TAOK2 GSK3B MTOR RIOK1 AURKB TRIO CDC42BPB VRK2 PSKH1
GO GO:0004697 GO: 0004697: protein kinase C act. P < 0.05 from the WTCCC PBAs PRKCE PRKCZ
GO GO:0004716 GO: 0004716: receptor signaling protein tyrosine kinase act. P < 0.05 from the WTCCC PBAs ERBB4 EGFR
GO GO:0004879 GO: 0004879: ligand-dependent nuclear receptor act. P < 0.05 from the WTCCC PBAs NR1D1 RORB RORA NR4A2 AHR PPARD HNF4A
GO GO:0004935 GO: 0004935: adrenoceptor act. P < 0.05 from the WTCCC PBAs
GO GO:0004952 GO: 0004952: dopamine receptor act. P < 0.05 from the WTCCC PBAs DRD1 DRD5 DRD4
GO GO:0005021 GO: 0005021: vascular endothelial growth factor receptor act. P < 0.05 from the WTCCC PBAs
GO GO:0005085 GO: 0005085: guanyl-nucleotide exchange factor act. P < 0.05 from the WTCCC PBAs TIAM2 DOCK3 TRIO
GO GO:0005089 GO: 0005089: Rho guanyl-nucleotide exchange factor act. P < 0.05 from the WTCCC PBAs FARP1 BCR ARHGEF5 TRIO RASGRF2 TIAM2 DOCK9
GO GO:0005216 GO: 0005216: ion channel act. P < 0.05 from the WTCCC PBAs HTR3B CHRNA1
GO GO:0005244 GO: 0005244: voltage-gated ion channel act. P < 0.05 from the WTCCC PBAs KCNK10 KCNIP4
GO GO:0005248 GO: 0005248: voltage-gated Na+ channel act. P < 0.05 from the WTCCC PBAs SCN7A SCN8A
GO GO:0005251 GO: 0005251: delayed rectiWer K+ channel act. P < 0.05 from the WTCCC PBAs KCNQ2 KCNQ3 KCND2
GO GO:0005262 GO: 0005262: Ca2+ channel act. P < 0.05 from the WTCCC PBAs GRIN3A CACNB2 CHRNA9 GRIN2A RYR2 GRIN2B CHRNA10 TRPM2 GRIN1
GO GO:0005267 GO: 0005267: K+ channel act. P < 0.05 from the WTCCC PBAs KCNK10 KCNQ3 KCNQ2 KCNIP4
GO GO:0005496 GO: 0005496: steroid binding P < 0.05 from the WTCCC PBAs NR3C1 AKR1D1 ESR1 NR3C2
GO GO:0005509 GO: 0005509: Ca2+ ion binding P < 0.05 from the WTCCC PBAs NCALD CDH7 PITPNM2 MMP3 PLA2G1B DST OC90 PON1 EPDR1 TLL2 GRIN1 ANXA1 CACNA1E CCBE1 FBN1 NCAN CDH13 LRP8 HSPA5 DGKB MYL12B CACNA1B ITIH1 PCDH15 MMP16 CAMKK2 NOTCH4 SVEP1 NOTCH3 CDHR3 FBLN2 HSP90B1 MYL12A FSTL4 GRM7 SLIT3 SRR PPP3CB RYR2 NRXN1 PLCG1 UMOD KCNIP4 FSTL5 PNLIPRP1 ATP2A2 S100B GCH1 CDH15 GUCA1A
GO GO:0005516 GO: 0005516: calmodulin binding P < 0.05 from the WTCCC PBAs CAMK2A WFS1 GRIN1 RASGRF2 MYO5B RGS4 NRGN RYR2 GRM4 PCNT NOS3 NOS1 CACNA1C KCNN3 CAMKK2 PLA2G6 MYH14 PPP3CB PPP3CC VAMP2
GO GO:0005544 GO: 0005544: Ca2+-dependent phospholipid binding P < 0.05 from the WTCCC PBAs ANXA1
GO GO:0008067 GO: 0008067: metabotropic glutamate, GABA-B-like receptor act. P < 0.05 from the WTCCC PBAs
GO GO:0008188 GO: 0008188: neuropeptide receptor act. P < 0.05 from the WTCCC PBAs HCRTR1 SORCS2 NPFFR2 MCHR1 HCRTR2
GO GO:0008239 GO: 0008239: dipeptidyl-peptidase act. P < 0.05 from the WTCCC PBAs DPP10 NAALAD2 DPP6
GO GO:0008301 GO: 0008301: DNA bending act. P < 0.05 from the WTCCC PBAs TFAM
GO GO:0008509 GO: 0008509: anion transmembrane transporter act. P < 0.05 from the WTCCC PBAs
GO GO:0015085 GO: 0015085: Ca2+ ion transmembrane transporter act. P < 0.05 from the WTCCC PBAs
GO GO:0015269 GO: 0015269: Ca2+-activated K+ channel act. P < 0.05 from the WTCCC PBAs KCNMB2
GO GO:0015277 GO: 0015277: kainate selective glutamate receptor act. P < 0.05 from the WTCCC PBAs GRIK2 GRIK3 GRIK4 GRIK5
GO GO:0015297 GO: 0015297: antiporter act. P < 0.05 from the WTCCC PBAs
GO GO:0016524 GO: 0016524: latrotoxin receptor act. P < 0.05 from the WTCCC PBAs
GO GO:0016740 GO: 0016740: transferase act. P < 0.05 from the WTCCC PBAs
GO GO:0016757 GO: 0016757: transferase act., transferring glycosyl groups P < 0.05 from the WTCCC PBAs GLT8D1 LARGE
GO GO:0016758 GO: 0016758: transferase act., transferring hexosyl groups P < 0.05 from the WTCCC PBAs GGTA1P ALG10B
GO GO:0019992 GO: 0019992: diacylglycerol binding P < 0.05 from the WTCCC PBAs
GO GO:0030246 GO: 0030246: carbohydrate binding P < 0.05 from the WTCCC PBAs NCAN PLA2R1 ACAN ATRNL1 GALNT13 SIGLEC6
GO GO:0043565 GO: 0043565: sequence-speciWc DNA binding P < 0.05 from the WTCCC PBAs GLI2 TCF7L1 TFAP2B POU3F2 NR2E1 NR3C2 HES1 FOXO3 MEOX2 CUX2 TCF7L2 CLOCK PPARD THRA TRIM24 RORA ATF4 BCL2 AHR TSNAX GSC2 FOXP2 RORB CSRNP2 FOXN3 ARNTL ZNF274 EGR1 HOXA3
GO GO:0045296 GO: 0045296: cadherin binding P < 0.05 from the WTCCC PBAs NUMB CTNNA3 ANK3 P2RX4 PTPRT VCL CDH13

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback Acknowledgements
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Last update: March 31, 2016