Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	IL17RA
Previous Symbol	IL17R
Symbol Alias	hIL-17R, IL-17RA, CDw217, CD217
Approved Name	interleukin 17 receptor A
Previous Name	interleukin 17 receptor
Location	22q11.1
Position	chr22:17084954-17115694, 1
External Links	HGNC: 5985 Entrez Gene: 23765 Ensembl: ENSG00000177663 UCSC: uc002zly.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		2 SNP typed, Median D'=1, Median r<sup>2</sup> =0.56, 1 LD blocks, 0.07 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005887	integral component of plasma membrane	cellular component	NAS[9367539]	158

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030368	interleukin-17 receptor activity	molecular function	NAS[9367539]	1
GO:0032747	positive regulation of interleukin-23 production	biological process	IDA[21145111]	2
GO:0005515	protein binding	molecular function	IPI[21993848]	563
GO:1900017	positive regulation of cytokine production involved in inflammatory response	biological process	IEA	1
GO:0072537	fibroblast activation	biological process	IDA[21145111]	1
GO:0007166	cell surface receptor signaling pathway	biological process	NAS[9367539]	23
GO:0005576	extracellular region	cellular component	IEA	97
GO:0019221	cytokine-mediated signaling pathway	biological process	NAS[9367539]	23

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04060	Cytokine-cytokine receptor interaction	17

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
IL17RA	IL17A	NO	in vitro;in vivo	9367539

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
22q11	chr22:15000000-25500000	1 (0/1/0)
Chr 22	chr22:0-50818468	2 (0/1/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is not suggestive to SZ/SZA.	Negative

Reference	ID in SZGene	Result Category
16380905	438	Negative

Gene relationship with MDD

View in gBrowse

Region: chr22:17084954..17115694 View in gBrowse