Gene Report

Basic Info
Approved Symbol GRIA1
Previous Symbol GLUR1
Symbol Alias GluA1, GLURA
Approved Name glutamate receptor, ionotropic, AMPA 1
Location 5q33
Position chr5:153489615-153813869, 1
External Links HGNC: 4571
Entrez Gene: 2890
Ensembl: ENSG00000155511
UCSC: uc003luy.4
No. of Studies 2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Shi, J., 2008 (b) SNP: rs1461225, rs2926835, rs2926837, rs6580038 rs2926835 in the GRIA1 gene reached gene-wide association (permutation P<0.05 for all SNPs of each gene). . None of these associations survived multiple testing for its own system (e.g., glutamatergic or serotoninergic) or all the five systems taken together (permutation adjusted P>0.05)。 Positive Comment on Study
Kerner, B.,2009 SNP: rs1864205, rs4385264, rs472792, rs490922, rs524610, rs524905 Our findings suggest that variations in GRIA1 may contribute to the pathophysiology of BP with psychotic features in some families Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 30)

GO terms by PBA (count: 5)

GO terms by database search (count: 25)

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 2)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 19)

Related other genetic factors
Gene related SNPs (count: 80)

Literature-origin SNPs (count: 10)

LD-proxies (count: 70)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr5:153489615..153813869 View in gBrowse
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