Gene Report

Basic Info
Approved Symbol SORCS2
Symbol Alias KIAA1329
Approved Name sortilin-related VPS10 domain containing receptor 2
Location 4p16.1
Position chr4:7192538-7742836, 1
External Links HGNC: 16698
Entrez Gene: 57537
Ensembl: ENSG00000184985
UCSC: uc003gkb.4
No. of Studies 5 (Positive: 3; Negative: 2; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 5)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Xu, W., 2014 SNP: rs4292336 The SNP within or near this gene did not achieve genome-wide significance. Negative Comment on Study
Takata, A.,2011(a) SNP: rs10937823, rs11734984, rs11736984, rs12645507, rs13139074, rs16840892, rs34058821, rs4411993 In the association analysis using Japanese samples, a SNP in SORCS2 (rs10937823) showed nominal genotypic association. Positive Comment on Study
Ollila, H. M.,2009 SNP: rs10937823, rs4411993, rs7683874 we could confirm findings for this association with BPI. Positive Comment on Study
Yosifova, A.,2009 SNP: rs4411993 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Johnson, C.,2009 Monte-Carlo Simulation P-value = 0.0016. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 4)

GO terms by PBA (count: 3)

GO terms by database search (count: 1)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 51)

Literature-origin SNPs (count: 11)

LD-proxies (count: 40)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr4:7192538..7742836 View in gBrowse
View in gBrowse