Gene Report

Basic Info
Approved Symbol RELN
Symbol Alias RL, PRO1598
Approved Name reelin
Location 7q22
Position chr7:103471784-103989516, -1
External Links HGNC: 9957
Entrez Gene: 5649
Ensembl: ENSG00000189056
UCSC: uc010liz.3
No. of Studies 3 (Positive: 1; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Noor A., 2014 Selected stringent CNV related to this gene is not validated by qPCR from BD case data. Negative Comment on Study
Goes, F. S., 2010 SNP: rs17281921, rs2249372, rs362642, rs362719, rs362726, rs362814, rs7341475 rs362719 in this gene showed strong significance with BD, especially for females. Positive Comment on Study
Pisante, A.,2009 SNP: rs7341475 No association was found for BD (women or men). Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 50)

GO terms by PBA (count: 5)

GO terms by database search (count: 45)

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 2)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 1)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 8)

Literature-origin SNPs (count: 7)

LD-proxies (count: 1)

Gene related CNVs (count: 1)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 12)

Gene relationship with MDD

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Region: chr7:103471784..103989516 View in gBrowse
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