Gene Report

Basic Info
Approved Symbol DBH
Symbol Alias DBM
Approved Name dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Location 9q34
Position chr9:133636360-133659344, 1
External Links HGNC: 2689
Entrez Gene: 1621
Ensembl: ENSG00000123454
UCSC: uc004cel.3
No. of Studies 3 (Positive: 1; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Hess, C.,2009 SNP: rs1611115 No differences in DBH C-1021T genotype distribution were observed between patients with affective disorders and healthy control subjects. Negative Comment on Study
Ates, O.,2013 SNP: rs1611115, rs1108580, rs6271 Our data suggests that the 1603C>T polymorphism of the DBH gene is associated with susceptibility to bipolar disorder in Turkish population. Positive Comment on Study
Kirov, G.,1999(a) Other variant: DBH_A304S No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 36)

GO terms by PBA (count: 3)

GO terms by database search (count: 33)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 4)

Literature-origin SNPs (count: 3)

LD-proxies (count: 1)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 14)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr9:133636360..133659344 View in gBrowse
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