Gene Report

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Basic Info

Approved Symbol	LINGO2
Previous Symbol	LRRN6C
Symbol Alias	LERN3
Approved Name	leucine rich repeat and Ig domain containing 2
Previous Name	leucine rich repeat neuronal 6C
Location	9p21.2
Position	chr9:27948078-28670286, -1
External Links	HGNC: 21207 Entrez Gene: 158038 Ensembl: ENSG00000174482 UCSC: uc003zqu.2
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Malhotra, D.,2011		A de novo CNV related with this gene is discovered and validated in our study	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Malhotra[2011]_7	chr9:28639667-28696714 (NCBI Build 36 (hg18))	57048	9p21.1	deletion	De Novo

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
9p22.3-p21.1	chr9:14200000-33200000	1 (0/0/1)
Chr 9	chr9:0-138394717	3 (0/3/0)
9p21	chr9:19900000-33200000	2 (0/1/1)
9p21-p12	chr9:19900000-40000000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr9:27948078..28670286 View in gBrowse