Gene Report

Basic Info
Approved Symbol IGF1
Symbol Alias IGF1A, IGFI, IGF-I
Approved Name insulin-like growth factor 1 (somatomedin C)
Location 12q23.2
Position chr12:102395867-102480645, -1
External Links HGNC: 5464
Entrez Gene: 3479
Ensembl: ENSG00000017427
UCSC: uc001tjp.4
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Pereira, A. C.,2011 SNP: rs1019731, rs10745940, rs10860857, rs10860860, rs10860864, rs10860869, rs11111243, rs11111272, rs11829367, rs12309723, rs12423791, rs12426318, rs12821878, rs17439974, rs17727841, rs2072592, rs2114913, rs2195243, rs2373721, rs2607983, rs2607986, rs2946831, rs35762, rs35765, rs4764695, rs4764698, rs55650342, rs5742612, rs5742615, rs5742620, rs5742632, rs5742652, rs5742678, rs5742688, rs6214, rs703542, rs703548, rs7313075, rs75244810, rs753479, rs78352613, rs7955640, rs7978777, rs855288, rs860598, rs9308315, rs978458
Haplotype: IGF1_(CA)n - rs2195243 - rs12309723(306-G-A), rs11111243 - rs10860857 - rs4764695 - rs10860860 - rs2946831(C-C-C-T-A)
Other variant: IGF1_(CA)n
These data implicate IGF1 as a candidate gene to cause genetic susceptibility to BD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 90)

GO terms by PBA (count: 4)

GO terms by database search (count: 86)

Gene related KEGG pathways (count: 7)

KEGG pathways by PBA (count: 4)

KEGG pathways by database search (count: 3)

Gene related BioCarta pathways (count: 8)

Gene related interactors from protein-protein interactions data in HPRD (count: 14)

Related other genetic factors
Gene related SNPs (count: 84)

Literature-origin SNPs (count: 47)

LD-proxies (count: 37)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

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Region: chr12:102395867..102480645 View in gBrowse
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