Gene Report

Basic Info
Approved Symbol GRIN1
Previous Symbol NMDAR1
Symbol Alias GluN1
Approved Name glutamate receptor, ionotropic, N-methyl D-aspartate 1
Previous Name N-methyl-D-aspartate receptor subunit NR1
Location 9q34.3
Position chr9:137138390-137168762, 1
External Links HGNC: 4584
Entrez Gene: 2902
Ensembl: ENSG00000176884
UCSC: uc004cln.3
No. of Studies 3 (Positive: 2; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Georgi, A., 2006 SNP: rs10747050, rs11146020, rs4880213, rs6293 Our results do not support an association of the GRIN1 gene with BD in the German population. Negative Comment on Study
Mundo, E.,2003 Haplotype: (GRIN1_1001G/C) - (GRIN1_19700A/G) - (GRIN1_6608A/G)()
Other variant: GRIN1_exon6_19700A/G, GRIN1_intron11_6608A/G, GRIN1_promoter_1001G/C
If these results are replicated there could be important implications for the involvement of the GRIN1 in the pathogenesis of BP. Positive Comment on Study
Yosifova, A.,2009 SNP: rs11146020, rs1126442, rs2301363 Significant association of SNP in this gene with BD in our population was observed. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 75)

GO terms by PBA (count: 12)

GO terms by database search (count: 63)

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 2)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 2)

Gene related interactors from protein-protein interactions data in HPRD (count: 32)

Related other genetic factors
Gene related SNPs (count: 9)

Literature-origin SNPs (count: 6)

LD-proxies (count: 3)

Gene related CNVs (count: 0)

Gene related other variants (count: 3)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 13)

Gene relationship with MDD

View in gBrowse

Region: chr9:137138390..137168762 View in gBrowse
View in gBrowse