Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	GLT8D1
Symbol Alias	AD-017, FLJ14611
Approved Name	glycosyltransferase 8 domain containing 1
Location	3p21.1
Position	chr3:52694485-52706083, -1
External Links	HGNC: 24870 Entrez Gene: 55830 Ensembl: ENSG00000016864 UCSC: uc003dfi.5
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BD:Smallest P-value per gene=0.00535, Product of P truncation <=0.01=0.00535, Product of P truncation <=0.001=NA. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016020	membrane	cellular component	IDA[19946888]	137
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0016757	transferase activity, transferring glycosyl groups	molecular function	IEA	2

GO terms by database search (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008152	metabolic process	biological process	IEA	50

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 14)

Literature-origin SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2289247	chr3:52693241 - 52693241(1)	downstream_gene_variant; missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(1/0/0)
rs11130317	chr3:52697467 - 52697467(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(1/0/0)

LD-proxies (count: 12)

rs_ID	Location	Functional Annotation
rs6976	chr3:52694788 - 52694788(1)	3_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant
rs3733041	chr3:52697582 - 52697582(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs12635140	chr3:52704149 - 52704149(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs8906	chr3:52705504 - 52705504(1)	5_prime_UTR_variant; downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs11235	chr3:52711071 - 52711071(1)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant
rs13079063	chr3:52710444 - 52710444(1)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant
rs2164885	chr3:52697253 - 52697253(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs34017441	chr3:52708397 - 52708397(1)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant
rs6762813	chr3:52692679 - 52692679(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs6617	chr3:52706166 - 52706166(1)	5_prime_UTR_variant; downstream_gene_variant; intron_variant; missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs3755798	chr3:52707144 - 52707144(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs6445534	chr3:52709368 - 52709368(1)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3p21	chr3:43600000-54400000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
19065143	In SZ:Smallest P-value per gene=0.00608, Product of P truncation <=0.01=0.00608, Product of P truncation <=0.001=NA It showed evidence for association with SZ.	Positive

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

Reference	Description	Category in MDD	Link in MK4MDD
24373612	Gene expression microarray analysis of whole blood samples in 39 MDD patients and 40 healthy controls showed that rs2535629 has a strong influence on the expression levels of ITIH4 and GLT8D1.	Pos	GLT8D1

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Region: chr3:52694485..52706083 View in gBrowse