Gene Report

Basic Info
Approved Symbol BCL2
Symbol Alias Bcl-2, PPP1R50
Approved Name B-cell CLL/lymphoma 2
Name Alias protein phosphatase 1, regulatory subunit 50
Location 18q21.3
Position chr18:63123346-63320128, -1
External Links HGNC: 990
Entrez Gene: 596
Ensembl: ENSG00000171791
UCSC: uc002lit.1
No. of Studies 2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ? NO
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Soeiro-de-Souza, M. G., 2013 Genotype and allele A frequency of the Bcl-2 did not differ between BD and control group, but the present findings reinforce a key role for glutamatergic system dysfunction in the pathophysiology of BD, potentially involving modulatory effects by Bcl-2 in the ACC. Negative Comment on Study
Uemura, T.,2011 SNP: rs956572 No significant differences were observed in the genotype frequencies or allele frequencies compared with healthy subjects among BD-I, BD-II. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 136)

GO terms by PBA (count: 8)

GO terms by database search (count: 128)

Gene related KEGG pathways (count: 8)

KEGG pathways by PBA (count: 3)

KEGG pathways by database search (count: 5)

Gene related BioCarta pathways (count: 14)

Gene related interactors from protein-protein interactions data in HPRD (count: 74)

Related other genetic factors
Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 8)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr18:63123346..63320128 View in gBrowse
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