Gene Report

Basic Info
Approved Symbol NOTCH3
Previous Symbol CADASIL
Symbol Alias CASIL
Approved Name notch 3
Previous Name Notch (Drosophila) homolog 3, "Notch homolog 3 (Drosophila)"
Location 19p13.2-p13.1
Position chr19:15159038-15200981, -1
External Links HGNC: 7883
Entrez Gene: 4854
Ensembl: ENSG00000074181
UCSC: uc002nan.3
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Ahearn, E. P.,2002 Two-point linkage analysis yielded negative results for all models. Multipoint linkage analysis yielded negative results except for Model 1a, in which a maximal LOD score was -1.24.Nonparametric analyses were nonsignificant(P>0.05) for D19S923 and D19S841.. Notch3 does not appear to be a candidate gene for BPD in this family. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 23)

GO terms by PBA (count: 4)

GO terms by database search (count: 19)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 12)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr19:15159038..15200981 View in gBrowse
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