Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

ADD to My Gene Set

Comment on Gene

View All Comments on Gene

Basic Info

Approved Symbol	ID1
Symbol Alias	dJ857M17.1.2, bHLHb24
Approved Name	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
Name Alias	DNA-binding protein inhibitor ID-1
Location	20q11
Position	chr20:31605283-31606515, 1
External Links	HGNC: 5360 Entrez Gene: 3397 Ensembl: ENSG00000125968 UCSC: uc002wwg.2
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Cruceanu, C., 2013	Other variant: ID1_Chr20:30193296_T/G	Rare variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 29)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045765	regulation of angiogenesis	biological process	IEA	4
GO:0005634	nucleus	cellular component	IC[15138269]	283
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	66

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0060426	lung vasculature development	biological process	IEA	3
GO:0048514	blood vessel morphogenesis	biological process	TAS[14522471]	3
GO:0032963	collagen metabolic process	biological process	IEA	2
GO:0010621	negative regulation of transcription by transcription factor localization	biological process	TAS[14522471]	1
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	biological process	IDA[15138269]	6
GO:0001886	endothelial cell morphogenesis	biological process	IEA	2
GO:0005794	Golgi apparatus	cellular component	IDA	60
GO:0007179	transforming growth factor beta receptor signaling pathway	biological process	TAS[14522471]	5
GO:0060425	lung morphogenesis	biological process	IEA	1
GO:0046677	response to antibiotic	biological process	IEA	4
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0031648	protein destabilization	biological process	IEA	5
GO:0030509	BMP signaling pathway	biological process	IEA	6
GO:0007623	circadian rhythm	biological process	IEA	40
GO:0043408	regulation of MAPK cascade	biological process	IEA	6
GO:0043534	blood vessel endothelial cell migration	biological process	TAS[14522471]	1
GO:0007507	heart development	biological process	IEA	20
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IEA	62
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0043066	negative regulation of apoptotic process	biological process	IEA	46
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IDA[15138269]	43
GO:0045668	negative regulation of osteoblast differentiation	biological process	IEA	3
GO:0001525	angiogenesis	biological process	TAS[14522471]	20
GO:0043392	negative regulation of DNA binding	biological process	IEA	1
GO:0005515	protein binding	molecular function	IPI[15694377]	563
GO:0046983	protein dimerization activity	molecular function	IEA	19

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04350	TGF-beta signaling pathway	10

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 13)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ID1	ELK1	NO	in vitro	10022839
ID1	MYOD1	NO	in vitro;in vivo;yeast 2-hybrid	9242638
ID1	TCF12	NO	yeast 2-hybrid	9242638
ID1	MYF6	NO	in vivo;yeast 2-hybrid	9242638
ID1	CASK	NO	in vitro;yeast 2-hybrid	15694377
ID1	MYF5	NO	in vitro;in vivo;yeast 2-hybrid	9242638
ID1	PSMD4	NO	in vitro;in vivo;yeast 2-hybrid	9235903
ID1	ELK4	NO	in vitro	10022839
ID1	IFI16	NO	in vitro;in vivo	11940648
ID1	TCF4	YES	in vivo	11591653
ID1	TCF3	NO	in vivo	11591653
ID1	MYOG	NO	in vivo;yeast 2-hybrid	9242638
ID1	RUNX1T1	NO	in vivo	11591653

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
ID1_Chr20:30193296_T/G	Missense	Chr20:30193296	1 (0/0/1)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 20	chr20:0-64444167	4 (0/3/1)
20p11-q13	chr20:17900000-64444167	1 (1/0/0)
20q11	chr20:28100000-39000000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr20:31605283..31606515 View in gBrowse