Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	ID1
Symbol Alias	dJ857M17.1.2, bHLHb24
Approved Name	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
Name Alias	DNA-binding protein inhibitor ID-1
Location	20q11
Position	chr20:31605283-31606515, 1
External Links	HGNC: 5360 Entrez Gene: 3397 Ensembl: ENSG00000125968 UCSC: uc002wwg.2
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Cruceanu, C., 2013	Other variant: ID1_Chr20:30193296_T/G	Rare variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 29)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045765	regulation of angiogenesis	biological process	IEA	4
GO:0005634	nucleus	cellular component	IC[15138269]	283
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	66

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0060426	lung vasculature development	biological process	IEA	3
GO:0048514	blood vessel morphogenesis	biological process	TAS[14522471]	3
GO:0032963	collagen metabolic process	biological process	IEA	2
GO:0010621	negative regulation of transcription by transcription factor localization	biological process	TAS[14522471]	1
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	biological process	IDA[15138269]	6
GO:0001886	endothelial cell morphogenesis	biological process	IEA	2
GO:0005794	Golgi apparatus	cellular component	IDA	60
GO:0007179	transforming growth factor beta receptor signaling pathway	biological process	TAS[14522471]	5
GO:0060425	lung morphogenesis	biological process	IEA	1
GO:0046677	response to antibiotic	biological process	IEA	4
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0031648	protein destabilization	biological process	IEA	5
GO:0030509	BMP signaling pathway	biological process	IEA	6
GO:0007623	circadian rhythm	biological process	IEA	40
GO:0043408	regulation of MAPK cascade	biological process	IEA	6
GO:0043534	blood vessel endothelial cell migration	biological process	TAS[14522471]	1
GO:0007507	heart development	biological process	IEA	20
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IEA	62
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0043066	negative regulation of apoptotic process	biological process	IEA	46
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IDA[15138269]	43
GO:0045668	negative regulation of osteoblast differentiation	biological process	IEA	3
GO:0001525	angiogenesis	biological process	TAS[14522471]	20
GO:0043392	negative regulation of DNA binding	biological process	IEA	1
GO:0005515	protein binding	molecular function	IPI[15694377]	563
GO:0046983	protein dimerization activity	molecular function	IEA	19

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04350	TGF-beta signaling pathway	10

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 13)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ID1	MYOG	NO	in vivo;yeast 2-hybrid	9242638
ID1	TCF4	YES	in vivo	11591653
ID1	MYF6	NO	in vivo;yeast 2-hybrid	9242638
ID1	ELK4	NO	in vitro	10022839
ID1	TCF3	NO	in vivo	11591653
ID1	IFI16	NO	in vitro;in vivo	11940648
ID1	RUNX1T1	NO	in vivo	11591653
ID1	ELK1	NO	in vitro	10022839
ID1	CASK	NO	in vitro;yeast 2-hybrid	15694377
ID1	MYOD1	NO	in vitro;in vivo;yeast 2-hybrid	9242638
ID1	MYF5	NO	in vitro;in vivo;yeast 2-hybrid	9242638
ID1	TCF12	NO	yeast 2-hybrid	9242638
ID1	PSMD4	NO	in vitro;in vivo;yeast 2-hybrid	9235903

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
ID1_Chr20:30193296_T/G	Missense	Chr20:30193296	1 (0/0/1)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 20	chr20:0-64444167	4 (0/3/1)
20p11-q13	chr20:17900000-64444167	1 (1/0/0)
20q11	chr20:28100000-39000000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr20:31605283..31606515 View in gBrowse