Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	ANXA1
Previous Symbol	ANX1, LPC1
Approved Name	annexin A1
Location	9q21.13
Position	chr9:73151757-73170393, 1
External Links	HGNC: 533 Entrez Gene: 301 Ensembl: ENSG00000135046 UCSC: uc004ajf.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Huang, J.,2010	SNP: rs3758354	Suggestive association was found in BD-II.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 66)

GO terms by PBA (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IDA	360
GO:0006954	inflammatory response	biological process	TAS[10882119]	23
GO:0030674	protein binding, bridging	molecular function	IDA[10908733]	8
GO:0005634	nucleus	cellular component	IDA[22056994]	283
GO:0005198	structural molecule activity	molecular function	IDA[10908733]	14
GO:0005102	receptor binding	molecular function	TAS[10882119]	37
GO:0005544	calcium-dependent phospholipid binding	molecular function	IDA[2138016]	1
GO:0005509	calcium ion binding	molecular function	IEA	50

GO terms by database search (count: 58)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0048306	calcium-dependent protein binding	molecular function	IPI[15226301]	7
GO:0043066	negative regulation of apoptotic process	biological process	TAS[16130169]	46
GO:0042493	response to drug	biological process	IEA	57
GO:0097350	neutrophil clearance	biological process	IMP[21957127]	1
GO:0005929	cilium	cellular component	IEA	10
GO:0070555	response to interleukin-1	biological process	IEA	4
GO:0030850	prostate gland development	biological process	IEA	2
GO:0005576	extracellular region	cellular component	TAS	97
GO:0042803	protein homodimerization activity	molecular function	IEA	71
GO:2000483	negative regulation of interleukin-8 secretion	biological process	IMP[22056994]	1
GO:0032355	response to estradiol	biological process	IEA	11
GO:0042629	mast cell granule	cellular component	IEA	2
GO:0010165	response to X-ray	biological process	IEA	3
GO:0031340	positive regulation of vesicle fusion	biological process	IDA[2138016]	1
GO:0007166	cell surface receptor signaling pathway	biological process	IEA	23
GO:0050482	arachidonic acid secretion	biological process	IEA	8
GO:0030216	keratinocyte differentiation	biological process	IDA[10908733]	3
GO:0046632	alpha-beta T cell differentiation	biological process	ISS	1
GO:0043234	protein complex	cellular component	IEA	27
GO:0001780	neutrophil homeostasis	biological process	IMP[21957127]	3
GO:0070365	hepatocyte differentiation	biological process	IEA	1
GO:0033676	double-stranded DNA-dependent ATPase activity	molecular function	IEA	1
GO:1900138	negative regulation of phospholipase A2 activity	biological process	IEA	2
GO:0030073	insulin secretion	biological process	IEA	6
GO:0031966	mitochondrial membrane	cellular component	IEA	3
GO:0003727	single-stranded RNA binding	molecular function	IEA	1
GO:0031018	endocrine pancreas development	biological process	IEA	6
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	biological process	IEA	3
GO:0003697	single-stranded DNA binding	molecular function	IEA	7
GO:0005615	extracellular space	cellular component	IDA[22664934]	85
GO:0005543	phospholipid binding	molecular function	TAS[2967291]	8
GO:0042063	gliogenesis	biological process	IEA	1
GO:0031394	positive regulation of prostaglandin biosynthetic process	biological process	IEA	1
GO:0007165	signal transduction	biological process	TAS[16130169]	136
GO:0070459	prolactin secretion	biological process	IEA	2
GO:0032508	DNA duplex unwinding	biological process	IEA	5
GO:0070301	cellular response to hydrogen peroxide	biological process	IEA	4
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0005925	focal adhesion	cellular component	IDA[21423176]	32
GO:0071385	cellular response to glucocorticoid stimulus	biological process	IDA[2936963]	4
GO:0036292	DNA rewinding	biological process	IEA	1
GO:0016323	basolateral plasma membrane	cellular component	IEA	21
GO:0009986	cell surface	cellular component	IDA[22056994]	40
GO:0000733	DNA strand renaturation	biological process	IEA	1
GO:0018149	peptide cross-linking	biological process	IDA[10908733]	2
GO:0042127	regulation of cell proliferation	biological process	IEA	14
GO:0001533	cornified envelope	cellular component	IDA[10908733]	2
GO:0004386	helicase activity	molecular function	IEA	4
GO:0005768	endosome	cellular component	IDA[18767904]	27
GO:0036310	annealing helicase activity	molecular function	IEA	1
GO:0006928	movement of cell or subcellular component	biological process	TAS[10882119]	7
GO:0043434	response to peptide hormone	biological process	IEA	9
GO:0031982	vesicle	cellular component	IDA[19190083]	20
GO:0042383	sarcolemma	cellular component	IEA	12
GO:0005515	protein binding	molecular function	IPI[21383699]	563
GO:0033031	positive regulation of neutrophil apoptotic process	biological process	IEA	2
GO:0005737	cytoplasm	cellular component	IDA; TAS[16130169]	322
GO:0019834	phospholipase A2 inhibitor activity	molecular function	IDA[2936963]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
gcrPathway	Corticosteroids and cardioprotection	9

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ANXA1	TGM2	YES	in vitro	1670773
ANXA1	FPR1	NO	in vitro;in vivo	10882119
ANXA1	S100A11	NO	in vitro;in vivo	12645011 , 8557678
ANXA1	KRT8	NO	in vivo	9459484
ANXA1	TRPM7	NO	in vitro;in vivo	15485879
ANXA1	DYSF	NO	in vitro	14506282
ANXA1	SRC	NO	in vitro	2457390
ANXA1	PRKCI	NO	in vitro	2457390

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3758354	chr9:73149649 - 73149649(1)	upstream_gene_variant	1(0/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
9q21-32	chr9:65000000-114900000	1 (0/1/0)
Chr 9	chr9:0-138394717	3 (0/3/0)
9q21-22	chr9:65000000-99800000	1 (0/1/0)
9q21	chr9:65000000-87800000	3 (1/1/1)
9p21.1-q21.32	chr9:28000000-84300000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
20713499	No significant association of this gene was observed in SZ.	Negative

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
20713499	No significant association was observed in MDD.	Negative

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr9:73151757..73170393 View in gBrowse