Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

ADD to My Gene Set

Comment on Gene

View All Comments on Gene

Basic Info

Approved Symbol	ANXA1
Previous Symbol	ANX1, LPC1
Approved Name	annexin A1
Location	9q21.13
Position	chr9:73151757-73170393, 1
External Links	HGNC: 533 Entrez Gene: 301 Ensembl: ENSG00000135046 UCSC: uc004ajf.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Huang, J.,2010	SNP: rs3758354	Suggestive association was found in BD-II.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 66)

GO terms by PBA (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IDA	360
GO:0006954	inflammatory response	biological process	TAS[10882119]	23
GO:0030674	protein binding, bridging	molecular function	IDA[10908733]	8
GO:0005634	nucleus	cellular component	IDA[22056994]	283
GO:0005198	structural molecule activity	molecular function	IDA[10908733]	14
GO:0005102	receptor binding	molecular function	TAS[10882119]	37
GO:0005544	calcium-dependent phospholipid binding	molecular function	IDA[2138016]	1
GO:0005509	calcium ion binding	molecular function	IEA	50

GO terms by database search (count: 58)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0048306	calcium-dependent protein binding	molecular function	IPI[15226301]	7
GO:0043066	negative regulation of apoptotic process	biological process	TAS[16130169]	46
GO:0042493	response to drug	biological process	IEA	57
GO:0097350	neutrophil clearance	biological process	IMP[21957127]	1
GO:0005929	cilium	cellular component	IEA	10
GO:0070555	response to interleukin-1	biological process	IEA	4
GO:0030850	prostate gland development	biological process	IEA	2
GO:0005576	extracellular region	cellular component	TAS	97
GO:0042803	protein homodimerization activity	molecular function	IEA	71
GO:2000483	negative regulation of interleukin-8 secretion	biological process	IMP[22056994]	1
GO:0032355	response to estradiol	biological process	IEA	11
GO:0042629	mast cell granule	cellular component	IEA	2
GO:0010165	response to X-ray	biological process	IEA	3
GO:0031340	positive regulation of vesicle fusion	biological process	IDA[2138016]	1
GO:0007166	cell surface receptor signaling pathway	biological process	IEA	23
GO:0050482	arachidonic acid secretion	biological process	IEA	8
GO:0030216	keratinocyte differentiation	biological process	IDA[10908733]	3
GO:0046632	alpha-beta T cell differentiation	biological process	ISS	1
GO:0043234	protein complex	cellular component	IEA	27
GO:0001780	neutrophil homeostasis	biological process	IMP[21957127]	3
GO:0070365	hepatocyte differentiation	biological process	IEA	1
GO:0033676	double-stranded DNA-dependent ATPase activity	molecular function	IEA	1
GO:1900138	negative regulation of phospholipase A2 activity	biological process	IEA	2
GO:0030073	insulin secretion	biological process	IEA	6
GO:0031966	mitochondrial membrane	cellular component	IEA	3
GO:0003727	single-stranded RNA binding	molecular function	IEA	1
GO:0031018	endocrine pancreas development	biological process	IEA	6
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	biological process	IEA	3
GO:0003697	single-stranded DNA binding	molecular function	IEA	7
GO:0005615	extracellular space	cellular component	IDA[22664934]	85
GO:0005543	phospholipid binding	molecular function	TAS[2967291]	8
GO:0042063	gliogenesis	biological process	IEA	1
GO:0031394	positive regulation of prostaglandin biosynthetic process	biological process	IEA	1
GO:0007165	signal transduction	biological process	TAS[16130169]	136
GO:0070459	prolactin secretion	biological process	IEA	2
GO:0032508	DNA duplex unwinding	biological process	IEA	5
GO:0070301	cellular response to hydrogen peroxide	biological process	IEA	4
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0005925	focal adhesion	cellular component	IDA[21423176]	32
GO:0071385	cellular response to glucocorticoid stimulus	biological process	IDA[2936963]	4
GO:0036292	DNA rewinding	biological process	IEA	1
GO:0016323	basolateral plasma membrane	cellular component	IEA	21
GO:0009986	cell surface	cellular component	IDA[22056994]	40
GO:0000733	DNA strand renaturation	biological process	IEA	1
GO:0018149	peptide cross-linking	biological process	IDA[10908733]	2
GO:0042127	regulation of cell proliferation	biological process	IEA	14
GO:0001533	cornified envelope	cellular component	IDA[10908733]	2
GO:0004386	helicase activity	molecular function	IEA	4
GO:0005768	endosome	cellular component	IDA[18767904]	27
GO:0036310	annealing helicase activity	molecular function	IEA	1
GO:0006928	movement of cell or subcellular component	biological process	TAS[10882119]	7
GO:0043434	response to peptide hormone	biological process	IEA	9
GO:0031982	vesicle	cellular component	IDA[19190083]	20
GO:0042383	sarcolemma	cellular component	IEA	12
GO:0005515	protein binding	molecular function	IPI[21383699]	563
GO:0033031	positive regulation of neutrophil apoptotic process	biological process	IEA	2
GO:0005737	cytoplasm	cellular component	IDA; TAS[16130169]	322
GO:0019834	phospholipase A2 inhibitor activity	molecular function	IDA[2936963]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
gcrPathway	Corticosteroids and cardioprotection	9

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ANXA1	TRPM7	NO	in vitro;in vivo	15485879
ANXA1	KRT8	NO	in vivo	9459484
ANXA1	PRKCI	NO	in vitro	2457390
ANXA1	DYSF	NO	in vitro	14506282
ANXA1	S100A11	NO	in vitro;in vivo	12645011 , 8557678
ANXA1	TGM2	YES	in vitro	1670773
ANXA1	SRC	NO	in vitro	2457390
ANXA1	FPR1	NO	in vitro;in vivo	10882119

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3758354	chr9:73149649 - 73149649(1)	upstream_gene_variant	1(0/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
9q21-32	chr9:65000000-114900000	1 (0/1/0)
Chr 9	chr9:0-138394717	3 (0/3/0)
9q21-22	chr9:65000000-99800000	1 (0/1/0)
9q21	chr9:65000000-87800000	3 (1/1/1)
9p21.1-q21.32	chr9:28000000-84300000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
20713499	No significant association of this gene was observed in SZ.	Negative

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
20713499	No significant association was observed in MDD.	Negative

Overlap with MDD from candidate gene intersection analysis (count: 0)

View in gBrowse

Region: chr9:73151757..73170393 View in gBrowse