Gene Report

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Basic Info

Approved Symbol	TLL2
Approved Name	tolloid-like 2
Location	10q23-q24
Position	chr10:96364606-96513918, -1
External Links	HGNC: 11844 Entrez Gene: 7093 Ensembl: ENSG00000095587 UCSC: uc001kml.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
de Mooij-van Malsen JG, 2013	SNP: rs2861579, rs10786291	By using the combined control dataset, a significant association was found for TLL2.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005509	calcium ion binding	molecular function	IEA	50
GO:0030154	cell differentiation	biological process	IEA	31
GO:0004222	metalloendopeptidase activity	molecular function	IEA	8
GO:0007275	multicellular organismal development	biological process	IEA	24

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005576	extracellular region	cellular component	TAS	97
GO:0006508	proteolysis	biological process	IEA	34
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0022617	extracellular matrix disassembly	biological process	TAS	10
GO:0030198	extracellular matrix organization	biological process	TAS	26

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2861579	chr10:96447544 - 96447544(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)
rs10786291	chr10:96463245 - 96463245(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10q22.1-q24.1	chr10:68800000-97500000	1 (1/0/0)
10q22.3-24.1	chr10:75900000-97500000	1 (0/1/0)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q24	chr10:95300000-104000000	4 (0/2/2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr10:96364606..96513918 View in gBrowse