Gene Report

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Basic Info

Approved Symbol	FRMD3
Symbol Alias	EPB41L4O, MGC20553
Approved Name	FERM domain containing 3
Location	9q21.33
Position	chr9:83242990-83538546, -1
External Links	HGNC: 24125 Entrez Gene: 257019 Ensembl: ENSG00000172159 UCSC: uc004ams.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs10117817, rs10746698, rs10780579, rs1323771	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0008092	cytoskeletal protein binding	molecular function	IEA	6

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0019898	extrinsic component of membrane	cellular component	IEA	8
GO:0005856	cytoskeleton	cellular component	IEA	30
GO:0005737	cytoplasm	cellular component	IEA	322

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 10)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3739657	chr9:83373020 - 83373020(1)	intron_variant	1(0/0/1)
rs10780579	chr9:83234543 - 83234543(1)	downstream_gene_variant	1(0/1/0)
rs1323771	chr9:83218212 - 83218212(1)	upstream_gene_variant	1(0/1/0)
rs10746698	chr9:83237384 - 83237384(1)	downstream_gene_variant	1(0/1/0)
rs10117817	chr9:83240685 - 83240685(1)	downstream_gene_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs10746699	chr9:83241195 - 83241195(1)	downstream_gene_variant
rs7043458	chr9:83239002 - 83239002(1)	downstream_gene_variant
rs4877746	chr9:83246282 - 83246282(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant
rs4877742	chr9:83245856 - 83245856(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant
rs4877750	chr9:83257749 - 83257749(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
9q21-32	chr9:65000000-114900000	1 (0/1/0)
Chr 9	chr9:0-138394717	3 (0/3/0)
9q21-22	chr9:65000000-99800000	1 (0/1/0)
9q21	chr9:65000000-87800000	3 (1/1/1)
9p21.1-q21.32	chr9:28000000-84300000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr9:83242990..83538546 View in gBrowse