Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	TFRC
Symbol Alias	CD71, TFR1, p90
Approved Name	transferrin receptor
Previous Name	transferrin receptor (p90, CD71)
Location	3q29
Position	chr3:196027183-196082189, -1
External Links	HGNC: 11763 Entrez Gene: 7037 Ensembl: ENSG00000072274 UCSC: uc003fwa.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Schosser, A.,2011	SNP: rs3817672	No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 33)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0016020	membrane	cellular component	NAS[1871153]	137
GO:0005887	integral component of plasma membrane	cellular component	TAS[6090955]	158

GO terms by database search (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0033572	transferrin transport	biological process	TAS	7
GO:0030316	osteoclast differentiation	biological process	IEA	2
GO:0009986	cell surface	cellular component	IDA[7556058]	40
GO:0070062	extracellular vesicular exosome	cellular component	IDA[20458337]	176
GO:0035690	cellular response to drug	biological process	IDA[16254249]	13
GO:0006879	cellular iron ion homeostasis	biological process	NAS[1871153]; TAS	7
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA	34
GO:0055037	recycling endosome	cellular component	IDA[22456507]	14
GO:0016023	cytoplasmic membrane-bounded vesicle	cellular component	IDA[15229288]	16
GO:0005905	coated pit	cellular component	IDA[12857860]	4
GO:0006898	receptor-mediated endocytosis	biological process	IEA	12
GO:0004998	transferrin receptor activity	molecular function	NAS[1871153]	1
GO:0042127	regulation of cell proliferation	biological process	IMP[7556058]	14
GO:0097286	iron ion import	biological process	IDA[7556058]	1
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674]	44
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[20202662]	50
GO:0016032	viral process	biological process	IEA	26
GO:0005576	extracellular region	cellular component	IDA[1871153]	97
GO:0072562	blood microparticle	cellular component	IDA[22516433]	8
GO:0005768	endosome	cellular component	IDA[14612438]	27
GO:0001558	regulation of cell growth	biological process	IMP[7556058]	7
GO:0005515	protein binding	molecular function	IPI[10638746]	563
GO:0042470	melanosome	cellular component	IEA	15
GO:0055085	transmembrane transport	biological process	TAS	77
GO:0042802	identical protein binding	molecular function	IPI[23384347]	44
GO:0009897	external side of plasma membrane	cellular component	IEA	21
GO:0003725	double-stranded RNA binding	molecular function	IDA[21266579]	9
GO:0005615	extracellular space	cellular component	IDA[22664934]	85
GO:0045780	positive regulation of bone resorption	biological process	IEA	2
GO:0031982	vesicle	cellular component	IDA[24769233]	20

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04640	Hematopoietic cell lineage	5

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
eea1Pathway	The role of FYVE-finger proteins in vesicle transport	2

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TFRC	CD4	NO	in vivo	14705953
TFRC	RANBP9	NO	in vivo	14722085
TFRC	CD247	NO	in vitro;in vivo	9448136
TFRC	GABARAP	NO	in vitro;in vivo;yeast 2-hybrid	11997026
TFRC	HFE	NO	in vitro;in vivo	9465039
TFRC	RAB5B	NO	in vivo	7789520
TFRC	ACAP1	NO	in vitro;in vivo	15525538
TFRC	TF	NO	in vivo	12210842 , 6268632 , 16354665

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3817672	chr3:196073940 - 196073940(1)	downstream_gene_variant; intron_variant; missense_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3q29	chr3:192600000-198295559	2 (1/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
17893707	577	Negative

Gene relationship with MDD

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Region: chr3:196027183..196082189 View in gBrowse