Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	APOD
Approved Name	apolipoprotein D
Location	3q29
Position	chr3:195568702-195584205, -1
External Links	HGNC: 612 Entrez Gene: 347 Ensembl: ENSG00000189058 UCSC: uc003fur.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Schosser, A.,2011	SNP: rs1568565, rs7629772, rs7659 Haplotype: rs1568565 - rs7629772()	No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 31)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007420	brain development	biological process	ISS	25
GO:0006869	lipid transport	biological process	NAS[3453108]	4

GO terms by database search (count: 29)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0001525	angiogenesis	biological process	NAS[21705670]	20
GO:0042246	tissue regeneration	biological process	ISS	2
GO:0042493	response to drug	biological process	ISS	57
GO:0030425	dendrite	cellular component	ISS	65
GO:0051895	negative regulation of focal adhesion assembly	biological process	IMP[21705670]	2
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	biological process	IDA[14551159]	1
GO:2000405	negative regulation of T cell migration	biological process	IDA[18842892]	1
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[14551159]	50
GO:0060588	negative regulation of lipoprotein lipid oxidation	biological process	IDA[18419796]	1
GO:0005615	extracellular space	cellular component	IDA[16502470]	85
GO:0042308	negative regulation of protein import into nucleus	biological process	IDA[14551159]	2
GO:1900016	negative regulation of cytokine production involved in inflammatory response	biological process	IDA[18842892]	1
GO:0005576	extracellular region	cellular component	NAS[14718574]	97
GO:0014012	peripheral nervous system axon regeneration	biological process	ISS	4
GO:0006006	glucose metabolic process	biological process	IDA[19176353]	10
GO:0007568	aging	biological process	NAS[20023409]	22
GO:0043025	neuronal cell body	cellular component	ISS	50
GO:0048662	negative regulation of smooth muscle cell proliferation	biological process	IDA[14551159]	7
GO:0048678	response to axon injury	biological process	ISS	4
GO:0015485	cholesterol binding	molecular function	IDA[9278274]	5
GO:2000098	negative regulation of smooth muscle cell-matrix adhesion	biological process	IMP[21705670]	1
GO:0000302	response to reactive oxygen species	biological process	IDA[18419796]	5
GO:0022626	cytosolic ribosome	cellular component	ISS	2
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0005319	lipid transporter activity	molecular function	NAS[3453108]	2
GO:0005783	endoplasmic reticulum	cellular component	ISS	49
GO:0006629	lipid metabolic process	biological process	IDA[19176353]	10
GO:0071638	negative regulation of monocyte chemotactic protein-1 production	biological process	IDA[18842892]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
APOD	APOA2	NO	in vitro	7918467
APOD	LEPR	YES	in vitro;in vivo;yeast 2-hybrid	11344130
APOD	GRINL1A	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 3)

Literature-origin SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7659	chr3:195568790 - 195568790(1)	3_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant	1(0/1/0)
rs7629772	chr3:195581532 - 195581532(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)
rs1568565	chr3:195574323 - 195574323(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3q29	chr3:192600000-198295559	2 (1/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Reference	ID in SZGene	Result Category
16402085	220	Negative
16966838	220	Negative

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

Reference	Description	Category in MDD	Link in MK4MDD
15303102	Genes altered in major depressive disorder	Pos	APOD

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Region: chr3:195568702..195584205 View in gBrowse