Gene Report

Basic Info
Approved Symbol GDNF
Symbol Alias ATF1, ATF2, HFB1-GDNF
Approved Name glial cell derived neurotrophic factor
Name Alias astrocyte-derived trophic factor, "glial cell line derived neurotrophic factor", "glial derived neurotrophic factor"
Location 5p13.1-p12
Position chr5:37812677-37839686, -1
External Links HGNC: 4232
Entrez Gene: 2668
Ensembl: ENSG00000168621
UCSC: uc011cpg.2
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Safari, R., 2014 SNP: rs2075680, rs79669773, rs62360370, rs142426358, rs78613670, rs147083416, rs115322727
Other variant: GDNF_Chr5:37812784_T/A, GDNF_Chr5:37812782_T/A, GDNF_Chr5:37814769_G/A
Our study proposes the suggestive association between polymorphisms in the potential regulatory sites of GDNF and bipolar disorder. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 34)

GO terms by PBA (count: 4)

GO terms by database search (count: 30)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 7)

Literature-origin SNPs (count: 7)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 3)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 4)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

View in gBrowse

Region: chr5:37812677..37839686 View in gBrowse
View in gBrowse