Gene Report

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Basic Info

Approved Symbol	CNTNAP5
Symbol Alias	caspr5, FLJ31966
Approved Name	contactin associated protein-like 5
Location	2q14.1
Position	chr2:124025287-124915287, 1
External Links	HGNC: 18748 Entrez Gene: 129684 Ensembl: ENSG00000155052 UCSC: uc002tno.4
No. of Studies	2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs2420864	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study
Djurovic, S.,2010	SNP: rs1529289, rs2420559, rs2699365, rs2901197	No significant association of this gene was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0007155	cell adhesion	biological process	IEA	42

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 19)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2420559	chr2:124152424 - 124152424(1)	intron_variant	1(0/1/0)
rs2699365	chr2:124158584 - 124158584(1)	intron_variant	1(0/1/0)
rs1529289	chr2:124158066 - 124158066(1)	intron_variant	1(0/1/0)
rs2420864	chr2:124459809 - 124459809(1)	intron_variant	1(0/1/0)
rs2901197	chr2:124134429 - 124134429(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs17727261	chr2:124524333 - 124524333(1)	missense_variant
rs11123021	chr2:124101459 - 124101459(1)	intron_variant; non_coding_transcript_variant
rs1439134	chr2:124112463 - 124112463(1)	intron_variant; non_coding_transcript_variant
rs2420858	chr2:124456142 - 124456142(1)	intron_variant
rs1898787	chr2:124146066 - 124146066(1)	intron_variant
rs2043886	chr2:124147969 - 124147969(1)	intron_variant
rs2043885	chr2:124098762 - 124098762(1)	intron_variant; non_coding_transcript_variant
rs1919839	chr2:124151875 - 124151875(1)	intron_variant
rs1530104	chr2:124164720 - 124164720(1)	intron_variant
rs4340523	chr2:124113611 - 124113611(1)	intron_variant; non_coding_transcript_variant
rs2699367	chr2:124165241 - 124165241(1)	intron_variant
rs11896523	chr2:124129555 - 124129555(1)	intron_variant; non_coding_transcript_variant
rs11896568	chr2:124129632 - 124129632(1)	intron_variant; non_coding_transcript_variant
rs4456715	chr2:124136832 - 124136832(1)	downstream_gene_variant; intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q14.3	chr2:121600000-129100000	1 (0/0/1)
2q12.3-q22.1	chr2:106700000-141500000	1 (0/1/0)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p11-q14	chr2:83100000-129100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:124025287..124915287 View in gBrowse