Gene Report

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Basic Info

Approved Symbol	PILRA
Symbol Alias	FDF03
Approved Name	paired immunoglobin-like type 2 receptor alpha
Location	7q22.1
Position	chr7:100367530-100400099, 1
External Links	HGNC: 20396 Entrez Gene: 29992 Ensembl: ENSG00000085514 UCSC: uc003uuo.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs201649203	Putative damaging exonic variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005886	plasma membrane	cellular component	IEA	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0070062	extracellular vesicular exosome	cellular component	IDA[20458337]	176
GO:0005515	protein binding	molecular function	IPI[10660620]	563
GO:0007165	signal transduction	biological process	IDA[10903717]	136
GO:0016032	viral process	biological process	IEA	26

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PILRA	PTPN11	NO	in vivo	10660620
PILRA	PTPN6	NO	in vivo	10660620 , 10903717
PILRA	FCAR	NO	in vitro	15085135

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs201649203	chr7:100397913 - 100397913(1)	downstream_gene_variant; intron_variant; splice_donor_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q21-31	chr7:77900000-127500000	1 (1/0/0)
7q22	chr7:98400000-107800000	1 (0/1/0)
Chr 7	chr7:0-159345973	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr7:100367530..100400099 View in gBrowse