Gene Report

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Basic Info

Approved Symbol	GNRH1
Previous Symbol	GRH, GNRH, LHRH
Approved Name	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Previous Name	gonadotropin-releasing hormone 1 (leutinizing-releasing hormone)
Location	8p21-p11.2
Position	chr8:25419260-25424654, -1
External Links	HGNC: 4419 Entrez Gene: 2796 Ensembl: ENSG00000147437 UCSC: uc003xem.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		3 SNP typed, Median D'=1, Median r<sup>2</sup> =0.17, 1 LD blocks, 0.34 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007275	multicellular organismal development	biological process	TAS[2867548]	24
GO:0005179	hormone activity	molecular function	TAS[2863757]	12
GO:0007565	female pregnancy	biological process	IEA	15

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0031960	response to corticosteroid	biological process	IEA	2
GO:0043066	negative regulation of apoptotic process	biological process	IEA	46
GO:0008285	negative regulation of cell proliferation	biological process	TAS[10832105]	41
GO:2000354	regulation of ovarian follicle development	biological process	IEA	1
GO:0007165	signal transduction	biological process	TAS[8692981]	136
GO:0005183	gonadotropin hormone-releasing hormone activity	molecular function	IEA	1
GO:0045471	response to ethanol	biological process	IEA	24
GO:0005576	extracellular region	cellular component	TAS	97
GO:0005615	extracellular space	cellular component	IEA	85
GO:0042698	ovulation cycle	biological process	IEA	2
GO:2001223	negative regulation of neuron migration	biological process	IEA	2
GO:0010468	regulation of gene expression	biological process	IEA	6
GO:0007267	cell-cell signaling	biological process	TAS[1310542]	29

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04912	GnRH signaling pathway	17

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
GNRH1	MEP1A	NO	in vitro	11278902
GNRH1	GNRHR	NO	in vivo	9414473

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8p21	chr8:19200000-29000000	2 (0/1/1)
Chr 8	chr8:0-145138636	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is not suggestive to SZ/SZA.	Negative

Reference	ID in SZGene	Result Category
16380905	307	Negative

Gene relationship with MDD

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Region: chr8:25419260..25424654 View in gBrowse