Gene Report

Basic Info
Approved Symbol GNRH1
Previous Symbol GRH, GNRH, LHRH
Approved Name gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Previous Name gonadotropin-releasing hormone 1 (leutinizing-releasing hormone)
Location 8p21-p11.2
Position chr8:25419260-25424654, -1
External Links HGNC: 4419
Entrez Gene: 2796
Ensembl: ENSG00000147437
UCSC: uc003xem.4
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Fallin, M. D.,2005 3 SNP typed, Median D'=1, Median r<sup>2</sup> =0.17, 1 LD blocks, 0.34 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 16)

GO terms by PBA (count: 3)

GO terms by database search (count: 13)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr8:25419260..25424654 View in gBrowse
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