Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	ASTN2
Symbol Alias	KIAA0634
Approved Name	astrotactin 2
Location	9q33
Position	chr9:116425225-117415070, -1
External Links	HGNC: 17021 Entrez Gene: 23245 Ensembl: ENSG00000148219 UCSC: uc004bjt.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Hu, X.,2010	Haplotype: rs10123629 - rs165730(), rs10123629 - rs6004133(), rs10124883 - rs165730(), rs10124883 - rs6004133(), rs10123629 - rs165596(), rs10123629 - rs178069(), rs10124883 - rs165596(), rs10124883 - rs178069()	Our results indicate that interactions between neurological pathway-related genes ASTN2 and SNAP29 or ASTN2 and PIK4CA, or other genes in linkage disequilibrium with any genes in these pairs, were risk factors of BPD, in both Caucasian and Chinese Han populations.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:2000009	negative regulation of protein localization to cell surface	biological process	IEA	1
GO:0005768	endosome	cellular component	IEA	27
GO:0060187	cell pole	cellular component	IEA	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 2)

ID	Location	Size	Band	Type	Inheritance
CNV_Zhang[2009]_196	chr9:118293597-118397730 (Affymetrix SNP 6.0 array reference genome)	104133		Singleton deletions
CNV_Zhang[2009]_187	chr9:118479893-118601081 (Affymetrix SNP 6.0 array reference genome)	121188		Singleton deletions

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 9	chr9:0-138394717	3 (0/3/0)
9q33	chr9:114900000-127500000	1 (0/0/1)
9q32-q33	chr9:112100000-127500000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr9:116425225..117415070 View in gBrowse