Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	ROBO2
Symbol Alias	KIAA1568
Approved Name	roundabout, axon guidance receptor, homolog 2 (Drosophila)
Previous Name	roundabout (axon guidance receptor, Drosophila) homolog 2
Location	3p12.3
Position	chr3:75906695-77649964, 1
External Links	HGNC: 10250 Entrez Gene: 6092 Ensembl: ENSG00000185008 UCSC: uc003dpy.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Kuo, P. H., 2014	SNP: rs13322211	Gene-based P-value (allelic model) =0.1065, P-value (additive model) =0.0878. ROBO2 stood out for their potential biological plausibility to be associated with bipolar illness.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 21)

GO terms by PBA (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007417	central nervous system development	biological process	NAS[9458045]	21
GO:0007420	brain development	biological process	IEP[10197527]	25
GO:0007411	axon guidance	biological process	ISS; TAS	60
GO:0016021	integral component of membrane	cellular component	IEA	219

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008046	axon guidance receptor activity	molecular function	ISS; NAS[9458045]	2
GO:0001656	metanephros development	biological process	ISS	8
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	biological process	IDA[12504588]	7
GO:0031290	retinal ganglion cell axon guidance	biological process	ISS	2
GO:0001657	ureteric bud development	biological process	IMP[17357069]	3
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0032870	cellular response to hormone stimulus	biological process	IEP[18566128]	9
GO:0051964	negative regulation of synapse assembly	biological process	ISS	1
GO:0005515	protein binding	molecular function	IPI[12504588]	563
GO:0030673	axolemma	cellular component	ISS	2
GO:0042802	identical protein binding	molecular function	IDA[12504588]	44
GO:0050772	positive regulation of axonogenesis	biological process	IDA[12504588]	4
GO:0021891	olfactory bulb interneuron development	biological process	ISS	2
GO:0016199	axon midline choice point recognition	biological process	ISS	1
GO:0009986	cell surface	cellular component	IDA[12504588]	40
GO:0050925	negative regulation of negative chemotaxis	biological process	IDA[11748139]	1
GO:0061364	apoptotic process involved in luteolysis	biological process	IEP[18566128]	2

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04360	Axon guidance	16

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ROBO2	ROBO1	NO	in vitro	12504588
ROBO2	OLFM2	NO	yeast 2-hybrid	16169070
ROBO2	CPE	NO	yeast 2-hybrid	16169070
ROBO2	UBQLN4	NO	yeast 2-hybrid	16713569
ROBO2	SLIT2	NO	in vitro	10102268
ROBO2	SSRP1	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 25)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs13322211	chr3:77176746 - 77176746(1)	intron_variant; NMD_transcript_variant	1(1/0/0)

LD-proxies (count: 24)

rs_ID	Location	Functional Annotation
rs4684028	chr3:77223504 - 77223504(1)	intron_variant; NMD_transcript_variant
rs7432274	chr3:77224760 - 77224760(1)	intron_variant; NMD_transcript_variant
rs7644620	chr3:77237622 - 77237622(1)	intron_variant; NMD_transcript_variant
rs7433226	chr3:77178873 - 77178873(1)	intron_variant; NMD_transcript_variant
rs4683971	chr3:77174887 - 77174887(1)	intron_variant; NMD_transcript_variant
rs7644019	chr3:77173823 - 77173823(1)	intron_variant; NMD_transcript_variant
rs7643662	chr3:77173473 - 77173473(1)	intron_variant; NMD_transcript_variant
rs7433790	chr3:77165800 - 77165800(1)	intron_variant; NMD_transcript_variant
rs7431408	chr3:77161052 - 77161052(1)	intron_variant; NMD_transcript_variant
rs7433251	chr3:77161011 - 77161011(1)	intron_variant; NMD_transcript_variant
rs7432300	chr3:77157936 - 77157936(1)	intron_variant; NMD_transcript_variant
rs4684019	chr3:77209072 - 77209072(1)	intron_variant; NMD_transcript_variant
rs1441963	chr3:77200727 - 77200727(1)	intron_variant; NMD_transcript_variant
rs9822245	chr3:77199099 - 77199099(1)	intron_variant; NMD_transcript_variant
rs7432109	chr3:77197578 - 77197578(1)	intron_variant; NMD_transcript_variant
rs6771293	chr3:77188498 - 77188498(1)	intron_variant; NMD_transcript_variant
rs7614752	chr3:77187018 - 77187018(1)	intron_variant; NMD_transcript_variant
rs6548485	chr3:77186747 - 77186747(1)	intron_variant; NMD_transcript_variant
rs6548484	chr3:77186680 - 77186680(1)	intron_variant; NMD_transcript_variant
rs9864444	chr3:77151014 - 77151014(1)	intron_variant; NMD_transcript_variant
rs6548482	chr3:77155223 - 77155223(1)	intron_variant; NMD_transcript_variant
rs7432686	chr3:77142864 - 77142864(1)	intron_variant; NMD_transcript_variant
rs7372287	chr3:77147636 - 77147636(1)	intron_variant; NMD_transcript_variant
rs6548479	chr3:77134977 - 77134977(1)	intron_variant; NMD_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:75906695..77649964 View in gBrowse