Gene Report

Basic Info
Approved Symbol YWHAH
Previous Symbol YWHA1
Approved Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
Previous Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
Name Alias 14-3-3 eta
Location 22q12.1-q13.1
Position chr22:31944461-31957603, 1
External Links HGNC: 12853
Entrez Gene: 7533
Ensembl: ENSG00000128245
UCSC: uc003alz.3
No. of Studies 3 (Positive: 2; Negative: 0; trend: 1)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Grover, D.,2009 SNP: rs2246704, rs2853884, rs3747158, rs4820059, rs933226
Other variant: YWHAH_5'UTR_(GCCTGCA)n
Our study adds to the evidence that YWHAH is implicated in both BP and schizophrenia. Positive Comment on Study
Pers, T. H.,2011 SNP: rs1049583, rs2858753, rs3761432, rs929036
Haplotype: rs3761432 - rs929036(C-G), rs3761432 - rs929036(G-A), rs3761432 - rs929036(G-G), rs3761432 - rs929036(T-G)
Our findings showed an association between BD and YWHAH variants. Positive Comment on Study
Fallin, M. D.,2005 8 SNP typed, Median D'=1, Median r<sup>2</sup> =0.35, 2 LD blocks, 1.23 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in BP.. This gene is suggestive to BP , not suggestive to SZ/SZA. Trend Comment on Study
Gene functional annotation
Gene related GO terms (count: 30)

GO terms by PBA (count: 4)

GO terms by database search (count: 26)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 11)

Gene related interactors from protein-protein interactions data in HPRD (count: 56)

Related other genetic factors
Gene related SNPs (count: 21)

Literature-origin SNPs (count: 9)

LD-proxies (count: 12)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 6)

Gene relationship with MDD

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Region: chr22:31944461..31957603 View in gBrowse
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