Gene Report

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Basic Info

Approved Symbol	PARVG
Approved Name	parvin, gamma
Location	22q13.31
Position	chr22:44172956-44219533, 1
External Links	HGNC: 14654 Entrez Gene: 64098 Ensembl: ENSG00000138964 UCSC: uc003bep.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Drago, A., 2016		Freq(Significant SNPs/total SNPs%)=0.03. This genes encodes for an actin-binding protein associated with focal contacts. Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IEA	360
GO:0003779	actin binding	molecular function	TAS[11171322]	24

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0031532	actin cytoskeleton reorganization	biological process	IEA	8
GO:0007160	cell-matrix adhesion	biological process	TAS[11171322]	11
GO:0005856	cytoskeleton	cellular component	TAS[11171322]	30
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0005925	focal adhesion	cellular component	IEA	32

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04510	Focal adhesion	22

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PARVG	ILK	NO	in vitro;in vivo;yeast 2-hybrid	16517730

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
22q12.3-13.32	chr22:31800000-49100000	1 (0/1/0)
Chr 22	chr22:0-50818468	2 (0/1/1)
22q12.3-q13.33	chr22:31800000-50818468	1 (1/0/0)
22q13	chr22:37200000-50818468	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr22:44172956..44219533 View in gBrowse