Gene Report

Basic Info
Approved Symbol IGFBP7
Symbol Alias MAC25, IGFBP-7, PSF, FSTL2
Approved Name insulin-like growth factor binding protein 7
Location 4q12
Position chr4:57030773-57110385, -1
External Links HGNC: 5476
Entrez Gene: 3490
Ensembl: ENSG00000163453
UCSC: uc003hcn.3
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? NO
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Xu, W., 2014 SNP: rs4865174 The SNP within or near this gene did not achieve genome-wide significance. Negative Comment on Study
Hattori, E.,2009 SNP: rs10516162 After the two-stage analysis, markers in this gene remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 16)

GO terms by PBA (count: 2)

GO terms by database search (count: 14)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Related other genetic factors
Gene related SNPs (count: 11)

Literature-origin SNPs (count: 2)

LD-proxies (count: 9)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr4:57030773..57110385 View in gBrowse
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