Gene Report

Basic Info
Approved Symbol CREB1
Approved Name cAMP responsive element binding protein 1
Location 2q34
Position chr2:207529737-207603431, 1
External Links HGNC: 2345
Entrez Gene: 1385
Ensembl: ENSG00000118260
UCSC: uc002vcc.3
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? NO
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Crisafulli, C.,2012 SNP: rs6740584 We failed to observe any association of the 14 SNPs genotypes or alleles with clinical improvement, response and remission rates as well as final outcomes in any of such disorders. Our findings suggest that 14 SNPs under investigation in our study do not influence diagnosis and treatment response in patients with MDD and BD. Negative Comment on Study
Li M, 2013 SNP: rs6785, rs2709370 Here, we studied the MDD-related gene CREB1 in a set of independent BD sample groups of European ancestry (a total of 64 888 subjects) and identified multiple SNPs significantly associated with BD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 65)

GO terms by PBA (count: 5)

GO terms by database search (count: 60)

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 3)

Gene related BioCarta pathways (count: 14)

Gene related interactors from protein-protein interactions data in HPRD (count: 34)

Related other genetic factors
Gene related SNPs (count: 32)

Literature-origin SNPs (count: 3)

LD-proxies (count: 29)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 9)

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Region: chr2:207529737..207603431 View in gBrowse
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