Gene Report

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Basic Info

Approved Symbol	DPY19L3
Approved Name	dpy-19-like 3 (C. elegans)
Location	19q13.11
Position	chr19:32405543-32485895, 1
External Links	HGNC: 27120 Entrez Gene: 147991 Ensembl: ENSG00000178904 UCSC: uc002ntg.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Smith, E. N.,2009	SNP: rs2111504	For the AA sample, SNPs with the strongest statistical evidence for association included rs2111504 in DPY19L3 at 19q13.11 (P=1.5E-06) and rs2769605 in NTRK2 at 9q21.33 (P=4.5E-05).	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0018406	protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	biological process	IBA	2
GO:0005637	nuclear inner membrane	cellular component	IBA	3
GO:0000030	mannosyltransferase activity	molecular function	IBA	3

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2111504	chr19:32426549 - 32426549(1)	intron_variant; non_coding_transcript_variant	1(0/0/1)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Lyudmila Georgieva[2014]_13	chr19:30861683-36685690 (UCSC build 37, hg19)	58247	19q12-q13.12	duplication

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
19p13-q13	chr19:0-58617616	1 (0/1/0)
Chr 19	chr19:0-58617616	2 (0/2/0)
19q13	chr19:31900000-58617616	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr19:32405543..32485895 View in gBrowse