Gene Report

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Basic Info

Approved Symbol	ROR2
Previous Symbol	NTRKR2, BDB, BDB1
Approved Name	receptor tyrosine kinase-like orphan receptor 2
Location	9q22
Position	chr9:91563091-91950162, -1
External Links	HGNC: 10257 Entrez Gene: 4920 Ensembl: ENSG00000169071 UCSC: uc004arj.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Bergen, S. E.,2012	SNP: rs7872515	No significant association was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0030154	cell differentiation	biological process	IEA	31
GO:0005887	integral component of plasma membrane	cellular component	TAS[1334494]	158
GO:0004714	transmembrane receptor protein tyrosine kinase activity	molecular function	IEA	5
GO:0007275	multicellular organismal development	biological process	TAS[1334494]	24

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007223	Wnt signaling pathway, calcium modulating pathway	biological process	IEA	1
GO:0030538	embryonic genitalia morphogenesis	biological process	IEA	2
GO:0008285	negative regulation of cell proliferation	biological process	IMP[19486338]	41
GO:0090090	negative regulation of canonical Wnt signaling pathway	biological process	IEA	9
GO:0017147	Wnt-protein binding	molecular function	IPI[19486338]	5
GO:0001756	somitogenesis	biological process	IEA	3
GO:0001502	cartilage condensation	biological process	IEA	2
GO:0007165	signal transduction	biological process	TAS[1334494]	136
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	biological process	IEA	3
GO:0005109	frizzled binding	molecular function	IEA	1
GO:0005524	ATP binding	molecular function	IEA	118
GO:0005515	protein binding	molecular function	IPI[22939624]	563
GO:0042472	inner ear morphogenesis	biological process	IEA	8
GO:0018108	peptidyl-tyrosine phosphorylation	biological process	IEA; TAS[1334494]	12
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological process	IEA	16
GO:0030335	positive regulation of cell migration	biological process	IDA[19486338]	16
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IEA	58
GO:0090263	positive regulation of canonical Wnt signaling pathway	biological process	IEA	9
GO:0030669	clathrin-coated endocytic vesicle membrane	cellular component	TAS	4
GO:0007254	JNK cascade	biological process	IEA	8

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ROR2	WNT5A	NO	in vitro	12839624
ROR2	MAGED1	NO	in vivo;yeast 2-hybrid	12754255
ROR2	FZD5	NO	in vivo	12839624
ROR2	FZD2	YES	in vitro;in vivo	12839624

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs3750440		chr9:91948734 - 91948734(1)	5_prime_UTR_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
9q21-32	chr9:65000000-114900000	1 (0/1/0)
Chr 9	chr9:0-138394717	3 (0/3/0)
9q21-22	chr9:65000000-99800000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
22688191	No significant association was observed in SZ.	Negative

Gene relationship with MDD

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Region: chr9:91563091..91950162 View in gBrowse