Gene Report

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Basic Info

Approved Symbol	AKAP10
Symbol Alias	D-AKAP2, PRKA10, MGC9414
Approved Name	A kinase (PRKA) anchor protein 10
Name Alias	dual-specificity A-kinase anchoring protein 2, "protein kinase A anchoring protein 10", "mitochondrial A kinase PPKA anchor protein 10"
Location	17p11.1
Position	chr17:19904302-19978343, -1
External Links	HGNC: 368 Entrez Gene: 11216 Ensembl: ENSG00000108599 UCSC: uc002gwo.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BP:Smallest P-value per gene=0.00024, Product of P truncation <=0.01=0.00016, Product of P truncation <=0.001=0.00022. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IDA	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007165	signal transduction	biological process	TAS[9326583]	136
GO:0038032	termination of G-protein coupled receptor signaling pathway	biological process	IEA	7
GO:0007596	blood coagulation	biological process	TAS	44
GO:0008104	protein localization	biological process	IEA	5
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0005829	cytosol	cellular component	TAS	223
GO:0005739	mitochondrion	cellular component	IBA	75

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
AKAP10	PDZK1	NO	in vitro;yeast 2-hybrid	14531806
AKAP10	PRKAR2A	NO	in vitro	9326583
AKAP10	SLC9A3R1	NO	in vitro	14531806
AKAP10	PRKAR1A	YES	in vitro;yeast 2-hybrid	9326583
AKAP10	PRKAR2B	NO	in vitro	9326583

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
17p12-q21.33	chr17:10800000-52100000	1 (0/1/0)
17p11	chr17:16100000-25100000	1 (0/1/0)
Chr 17	chr17:0-83257441	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	It showed no evidence for association with SZ.	Negative

Gene relationship with MDD

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Region: chr17:19904302..19978343 View in gBrowse