Gene Report

Basic Info
Approved Symbol CHRNA4
Previous Symbol EBN, EBN1
Symbol Alias BFNC
Approved Name cholinergic receptor, nicotinic, alpha 4 (neuronal)
Previous Name cholinergic receptor, nicotinic, alpha polypeptide 4
Name Alias acetylcholine receptor, nicotinic, alpha 4 (neuronal)
Location 20q13.33
Position chr20:63343223-63378401, -1
External Links HGNC: 1958
Entrez Gene: 1137
Ensembl: ENSG00000101204
UCSC: uc002yes.3
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Shi, J., 2007 SNP: rs2273502, rs755203 rs1948 showed nominally significant transmission bias; haploview analyses showed nominally significant transmission bias of rs1948-rs7178270-rs1316971-rs11633223; no evidence of interaction among these 19 cholinergic genes by FITF analysis and FDR correction was found Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 36)

GO terms by PBA (count: 7)

GO terms by database search (count: 29)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 2)

Literature-origin SNPs (count: 2)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

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Region: chr20:63343223..63378401 View in gBrowse
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