Gene Report

Basic Info
Approved Symbol GNL3
Symbol Alias C77032, E2IG3, MGC800, NS
Approved Name guanine nucleotide binding protein-like 3 (nucleolar)
Name Alias nucleostemin
Location 3p21.1
Position chr3:52681156-52694492, 1
External Links HGNC: 29931
Entrez Gene: 26354
Ensembl: ENSG00000163938
UCSC: uc003dfd.3
No. of Studies 2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
McMahon, F. J., 2010 SNP: rs2289247 A nonsynonymous variant rs2289247 in the gene GNL3 was significant in MDD and there was strong linkage disequilibrium (LD) between rs2251219 and rs2289247. Positive Comment on Study
Moskvina, V.,2009 In BD:Smallest P-value per gene=0.00792, Product of P truncation <=0.01=0.00797, Product of P truncation <=0.001=NA. It showed evidence for association with BD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 14)

GO terms by PBA (count: 2)

GO terms by database search (count: 12)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 13)

Literature-origin SNPs (count: 3)

LD-proxies (count: 10)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr3:52681156..52694492 View in gBrowse
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