Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	KIF5B
Previous Symbol	KNS1
Symbol Alias	KNS
Approved Name	kinesin family member 5B
Location	10p11.22
Position	chr10:32009010-32056431, -1
External Links	HGNC: 6324 Entrez Gene: 3799 Ensembl: ENSG00000170759 UCSC: uc001iwe.4
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Goes, F. S.,2012	SNP: rs1775715	OR = 1.18,P-value(Meta) = 0.00000513 Suggestive association was found.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 28)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007411	axon guidance	biological process	IBA	60
GO:0016020	membrane	cellular component	IDA[19946888]	137

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043268	positive regulation of potassium ion transport	biological process	IDA[19675065]	6
GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	molecular function	IBA	1
GO:0030705	cytoskeleton-dependent intracellular transport	biological process	IBA	2
GO:0090004	positive regulation of establishment of protein localization to plasma membrane	biological process	IDA[19675065]	6
GO:0016887	ATPase activity	molecular function	IBA	13
GO:0008017	microtubule binding	molecular function	ISS	10
GO:0031982	vesicle	cellular component	IDA[20682791]	20
GO:0044267	cellular protein metabolic process	biological process	TAS	28
GO:0005515	protein binding	molecular function	IPI[19164528]	563
GO:0042391	regulation of membrane potential	biological process	IDA[19675065]	13
GO:0035617	stress granule disassembly	biological process	ISS	1
GO:0005871	kinesin complex	cellular component	IBA	6
GO:0005524	ATP binding	molecular function	IEA	118
GO:0007028	cytoplasm organization	biological process	IEA	1
GO:0043005	neuron projection	cellular component	IEA	38
GO:0048471	perinuclear region of cytoplasm	cellular component	ISS	50
GO:0032230	positive regulation of synaptic transmission, GABAergic	biological process	IEA	5
GO:0030139	endocytic vesicle	cellular component	IEA	8
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0005874	microtubule	cellular component	IEA	24
GO:0047496	vesicle transport along microtubule	biological process	ISS	5
GO:0035253	ciliary rootlet	cellular component	IEA	1
GO:0003777	microtubule motor activity	molecular function	ISS	8
GO:0072383	plus-end-directed vesicle transport along microtubule	biological process	IEA	2
GO:0007018	microtubule-based movement	biological process	IBA	7
GO:0005815	microtubule organizing center	cellular component	IDA	10

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 12)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
KIF5B	YWHAQ	YES	in vivo	15324660
KIF5B	KIF5A	NO	in vivo	10964943
KIF5B	RRBP1	NO	in vitro;yeast 2-hybrid	15184079
KIF5B	NCOA2	NO	in vivo;yeast 2-hybrid	11986669
KIF5B	YWHAZ	NO	in vivo	15324660
KIF5B	SNAP25	YES	in vitro;in vivo;yeast 2-hybrid	12475239
KIF5B	NDRG1	NO	in vivo	17220478
KIF5B	KTN1	NO	in vitro;in vivo;yeast 2-hybrid	10913441
KIF5B	SNAP23	NO	in vitro;yeast 2-hybrid	12475239
KIF5B	YWHAB	NO	in vivo	15324660
KIF5B	YWHAG	NO	in vivo	15324660
KIF5B	KLC3	NO	in vivo	10491391

Related other genetic factors

Gene related SNPs (count: 8)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1775715	chr10:32020077 - 32020077(1)	intron_variant; non_coding_transcript_variant	1(0/0/1)

LD-proxies (count: 7)

rs_ID	Location	Functional Annotation
rs11008750	chr10:32049427 - 32049427(1)	intron_variant
rs1251363	chr10:32039598 - 32039598(1)	intron_variant
rs11594506	chr10:32050864 - 32050864(1)	intron_variant
rs12572072	chr10:32019043 - 32019043(1)	intron_variant; non_coding_transcript_variant
rs11593733	chr10:32013371 - 32013371(1)	downstream_gene_variant; intron_variant
rs1251386	chr10:32030186 - 32030186(1)	intron_variant
rs1755066	chr10:32020232 - 32020232(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10p11-p14	chr10:6600000-39800000	1 (0/1/0)
Chr 10	chr10:0-133797422	3 (0/2/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

Reference	Description	Category in MDD	Link in MK4MDD
18068248	Genes differentially expressed in major depression	Pos	KIF5B

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Region: chr10:32009010..32056431 View in gBrowse