Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	KIF5B
Previous Symbol	KNS1
Symbol Alias	KNS
Approved Name	kinesin family member 5B
Location	10p11.22
Position	chr10:32009010-32056431, -1
External Links	HGNC: 6324 Entrez Gene: 3799 Ensembl: ENSG00000170759 UCSC: uc001iwe.4
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Goes, F. S.,2012	SNP: rs1775715	OR = 1.18,P-value(Meta) = 0.00000513 Suggestive association was found.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 28)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007411	axon guidance	biological process	IBA	60
GO:0016020	membrane	cellular component	IDA[19946888]	137

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043268	positive regulation of potassium ion transport	biological process	IDA[19675065]	6
GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	molecular function	IBA	1
GO:0030705	cytoskeleton-dependent intracellular transport	biological process	IBA	2
GO:0090004	positive regulation of establishment of protein localization to plasma membrane	biological process	IDA[19675065]	6
GO:0016887	ATPase activity	molecular function	IBA	13
GO:0008017	microtubule binding	molecular function	ISS	10
GO:0031982	vesicle	cellular component	IDA[20682791]	20
GO:0044267	cellular protein metabolic process	biological process	TAS	28
GO:0005515	protein binding	molecular function	IPI[19164528]	563
GO:0042391	regulation of membrane potential	biological process	IDA[19675065]	13
GO:0035617	stress granule disassembly	biological process	ISS	1
GO:0005871	kinesin complex	cellular component	IBA	6
GO:0005524	ATP binding	molecular function	IEA	118
GO:0007028	cytoplasm organization	biological process	IEA	1
GO:0043005	neuron projection	cellular component	IEA	38
GO:0048471	perinuclear region of cytoplasm	cellular component	ISS	50
GO:0032230	positive regulation of synaptic transmission, GABAergic	biological process	IEA	5
GO:0030139	endocytic vesicle	cellular component	IEA	8
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0005874	microtubule	cellular component	IEA	24
GO:0047496	vesicle transport along microtubule	biological process	ISS	5
GO:0035253	ciliary rootlet	cellular component	IEA	1
GO:0003777	microtubule motor activity	molecular function	ISS	8
GO:0072383	plus-end-directed vesicle transport along microtubule	biological process	IEA	2
GO:0007018	microtubule-based movement	biological process	IBA	7
GO:0005815	microtubule organizing center	cellular component	IDA	10

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 12)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
KIF5B	SNAP25	YES	in vitro;in vivo;yeast 2-hybrid	12475239
KIF5B	NCOA2	NO	in vivo;yeast 2-hybrid	11986669
KIF5B	SNAP23	NO	in vitro;yeast 2-hybrid	12475239
KIF5B	KTN1	NO	in vitro;in vivo;yeast 2-hybrid	10913441
KIF5B	YWHAB	NO	in vivo	15324660
KIF5B	RRBP1	NO	in vitro;yeast 2-hybrid	15184079
KIF5B	YWHAZ	NO	in vivo	15324660
KIF5B	YWHAQ	YES	in vivo	15324660
KIF5B	NDRG1	NO	in vivo	17220478
KIF5B	KIF5A	NO	in vivo	10964943
KIF5B	YWHAG	NO	in vivo	15324660
KIF5B	KLC3	NO	in vivo	10491391

Related other genetic factors

Gene related SNPs (count: 8)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1775715	chr10:32020077 - 32020077(1)	intron_variant; non_coding_transcript_variant	1(0/0/1)

LD-proxies (count: 7)

rs_ID	Location	Functional Annotation
rs11008750	chr10:32049427 - 32049427(1)	intron_variant
rs1251363	chr10:32039598 - 32039598(1)	intron_variant
rs11594506	chr10:32050864 - 32050864(1)	intron_variant
rs12572072	chr10:32019043 - 32019043(1)	intron_variant; non_coding_transcript_variant
rs11593733	chr10:32013371 - 32013371(1)	downstream_gene_variant; intron_variant
rs1251386	chr10:32030186 - 32030186(1)	intron_variant
rs1755066	chr10:32020232 - 32020232(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10p11-p14	chr10:6600000-39800000	1 (0/1/0)
Chr 10	chr10:0-133797422	3 (0/2/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

Reference	Description	Category in MDD	Link in MK4MDD
18068248	Genes differentially expressed in major depression	Pos	KIF5B

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Region: chr10:32009010..32056431 View in gBrowse