Gene Report

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Basic Info

Approved Symbol	IL2RB
Previous Symbol	IL15RB
Symbol Alias	CD122
Approved Name	interleukin 2 receptor, beta
Previous Name	interleukin 15 receptor, beta
Location	22q13
Position	chr22:37125838-37175054, -1
External Links	HGNC: 6009 Entrez Gene: 3560 Ensembl: ENSG00000100385 UCSC: uc003aqv.1
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Yosifova, A.,2009	SNP: rs228942, rs84459, rs84460	No SNP of this gene had significant association with BD in our population.	Negative	Comment on Study
Fallin, M. D.,2005		7 SNP typed, Median D'=0.26, Median r<sup>2</sup> =0.01, 4 LD blocks, 0.09 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in BP and all SNP or haplotype P-value > 0.05 in SZ/SZA.. This gene is highly suggestive to BP , not suggestive to SZ/SZA.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005887	integral component of plasma membrane	cellular component	TAS[8514792]	158
GO:0016020	membrane	cellular component	IDA[19946888]	137

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007165	signal transduction	biological process	TAS[2785715]	136
GO:0019976	interleukin-2 binding	molecular function	ISS	1
GO:0009897	external side of plasma membrane	cellular component	ISS	21
GO:0019221	cytokine-mediated signaling pathway	biological process	IDA[7736574]	23
GO:0016032	viral process	biological process	IEA	26
GO:0006461	protein complex assembly	biological process	TAS[2467293]	11
GO:0004911	interleukin-2 receptor activity	molecular function	IDA[7736574]; TAS[2467293]	1
GO:0038110	interleukin-2-mediated signaling pathway	biological process	IDA[7736574]; TAS[2467293]	2
GO:0043066	negative regulation of apoptotic process	biological process	IDA[7736574]	46

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04060	Cytokine-cytokine receptor interaction	17
hsa04630	Jak-STAT signaling pathway	14

Gene related BioCarta pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
il2rbPathway	IL-2 Receptor Beta Chain in T cell Activation	6
il2Pathway	IL 2 signaling pathway	3

Gene related interactors from protein-protein interactions data in HPRD (count: 22)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
IL2RB	EIF3B	NO	in vivo	7693677
IL2RB	SHC1	NO	in vitro;in vivo	10602027 , 8294403
IL2RB	RAF1	NO	in vitro	1639773
IL2RB	SOCS3	NO	in vitro	10373548
IL2RB	GRB2	NO	in vitro	10602027
IL2RB	IL2RG	NO	in vivo	11886175
IL2RB	SHB	NO	in vivo	12200137
IL2RB	GNB2L1	NO	in vitro;in vivo	12960323
IL2RB	IL2RA	NO	in vivo	11886175
IL2RB	STAT3	NO	in vivo	10602027
IL2RB	PTPN6	NO	in vitro	9520455
IL2RB	LCK	NO	in vitro	2047859 , 10214954
IL2RB	IL15	NO	in vivo	8026467 , 9176231
IL2RB	STAT5B	NO	in vivo	10602027
IL2RB	IL2	NO	in vivo	11035066 , 8049354
IL2RB	STAT1	NO	in vivo	10602027
IL2RB	LYN	NO	in vitro;in vivo	1557373
IL2RB	CISH	NO	in vitro;in vivo	10514520
IL2RB	JAK3	NO	in vitro;in vivo	10825200 , 7973659 , 9553136
IL2RB	STAT5A	NO	in vivo	10602027
IL2RB	SYK	NO	in vitro	7600304
IL2RB	SOCS1	NO	in vivo	11133764

Related other genetic factors

Gene related SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs84460	chr22:37129691 - 37129691(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs228942	chr22:37128579 - 37128579(1)	missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(0/1/0)
rs84459	chr22:37129280 - 37129280(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs228945	chr22:37129840 - 37129840(1)	intron_variant; non_coding_transcript_variant
rs228941	chr22:37127681 - 37127681(1)	3_prime_UTR_variant; downstream_gene_variant
rs84458	chr22:37129168 - 37129168(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
22q12.3-13.32	chr22:31800000-49100000	1 (0/1/0)
Chr 22	chr22:0-50818468	2 (0/1/1)
22q12.3-q13.33	chr22:31800000-50818468	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is highly suggestive to BP , not suggestive to SZ/SZA.	Negative

Gene relationship with MDD

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Region: chr22:37125838..37175054 View in gBrowse