Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	CARTPT
Symbol Alias	CART
Approved Name	CART prepropeptide
Name Alias	cocaine and amphetamine regulated transcript
Location	5q13.2
Position	chr5:71719163-71721048, 1
External Links	HGNC: 24323 Entrez Gene: 9607 Ensembl: ENSG00000164326 UCSC: uc003kbv.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Jung, S. K., 2004	SNP: rs2239670	The AvaII polymorphism of the CART gene did not show association with bipolar disorder and schizophrenia.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 23)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007268	synaptic transmission	biological process	IEA	116

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008343	adult feeding behavior	biological process	ISS	2
GO:0005515	protein binding	molecular function	IPI[21982860]	563
GO:0007186	G-protein coupled receptor signaling pathway	biological process	ISS[15908120]	64
GO:0070253	somatostatin secretion	biological process	IEA	1
GO:0005615	extracellular space	cellular component	IDA[11711504]; ISS	85
GO:0032812	positive regulation of epinephrine secretion	biological process	IDA[11711504]	1
GO:0007218	neuropeptide signaling pathway	biological process	IEA	18
GO:0007165	signal transduction	biological process	TAS[8647455]	136
GO:0007267	cell-cell signaling	biological process	TAS[8647455]	29
GO:0050796	regulation of insulin secretion	biological process	IEA	24
GO:0045779	negative regulation of bone resorption	biological process	IMP[16614075]	2
GO:0051971	positive regulation of transmission of nerve impulse	biological process	IDA[11711504]	3
GO:0003674	molecular_function	molecular function	ND	24
GO:0070093	negative regulation of glucagon secretion	biological process	IEA	2
GO:0000186	activation of MAPKK activity	biological process	ISS[15908120]	6
GO:0045777	positive regulation of blood pressure	biological process	IDA[11711504]	4
GO:0045671	negative regulation of osteoclast differentiation	biological process	TAS[16614075]	4
GO:0001678	cellular glucose homeostasis	biological process	IDA[11711504]	3
GO:0030141	secretory granule	cellular component	IDA[21624661]	14
GO:0009267	cellular response to starvation	biological process	ISS	6
GO:0032099	negative regulation of appetite	biological process	ISS; TAS[11478874]	2
GO:0032922	circadian regulation of gene expression	biological process	ISS	22

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2239670	chr5:71719676 - 71719676(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5p13.3-q13.3	chr5:28900000-77600000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
15234472	The AvaII polymorphism of the CART gene did not show association with schizophrenia.	Negative

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
15234472	320	Negative

Gene relationship with MDD

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Region: chr5:71719163..71721048 View in gBrowse