Gene Report

Basic Info
Approved Symbol PLA2G1B
Previous Symbol PLA2, PPLA2, PLA2A
Approved Name phospholipase A2, group IB (pancreas)
Location 12q24.31
Position chr12:120322111-120327789, -1
External Links HGNC: 9030
Entrez Gene: 5319
Ensembl: ENSG00000170890
UCSC: uc001tyd.3
No. of Studies 4 (Positive: 1; Negative: 3; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 4)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Dikeos, D. G., 2006 Other variant: PLA2_1-8 allele No genetic association was observed between the gene for the pancreatic PLA2 on chromosome 12q23-q24.1 and bipolar disorder. Negative Comment on Study
Jacobsen, N.,1996 Other variant: PLA2_1-8 allele We have been unable to replicate the association in 127 Caucasian British DSMIII-R bipolar probands and 223 Caucasian British controls. Negative Comment on Study
Meira-Lima, I.,2003(a) Our results failed to demonstrate that the studied PLA2 polymorphisms were associated with an increased risk for BPAD in our sample. Negative Comment on Study
Dawson, E.,1995 Other variant: PLA2G1B_microsatellite polymorphisms Allele 122 bp was more common in controls (X<sup>2</sup> = 8.85, df = 1, P-value = 0.003) and allele 134 bp was more common in cases (X<sup>2</sup> = 5.62, df = 1, P-value = 0.02).. PLA2A shows significant association with bipolar disorder. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 43)

GO terms by PBA (count: 2)

GO terms by database search (count: 41)

Gene related KEGG pathways (count: 10)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Gene related regions (count: 6)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 3)

Gene relationship with MDD

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Region: chr12:120322111..120327789 View in gBrowse
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