Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	PLA2G1B
Previous Symbol	PLA2, PPLA2, PLA2A
Approved Name	phospholipase A2, group IB (pancreas)
Location	12q24.31
Position	chr12:120322111-120327789, -1
External Links	HGNC: 9030 Entrez Gene: 5319 Ensembl: ENSG00000170890 UCSC: uc001tyd.3
No. of Studies	4 (Positive: 1; Negative: 3; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 4)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Dikeos, D. G., 2006	Other variant: PLA2_1-8 allele	No genetic association was observed between the gene for the pancreatic PLA2 on chromosome 12q23-q24.1 and bipolar disorder.	Negative	Comment on Study
Jacobsen, N.,1996	Other variant: PLA2_1-8 allele	We have been unable to replicate the association in 127 Caucasian British DSMIII-R bipolar probands and 223 Caucasian British controls.	Negative	Comment on Study
Meira-Lima, I.,2003(a)		Our results failed to demonstrate that the studied PLA2 polymorphisms were associated with an increased risk for BPAD in our sample.	Negative	Comment on Study
Dawson, E.,1995	Other variant: PLA2G1B_microsatellite polymorphisms	Allele 122 bp was more common in controls (X<sup>2</sup> = 8.85, df = 1, P-value = 0.003) and allele 134 bp was more common in cases (X<sup>2</sup> = 5.62, df = 1, P-value = 0.02).. PLA2A shows significant association with bipolar disorder.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 43)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005102	receptor binding	molecular function	IDA[1918029]; IPI[7721806]	37
GO:0005509	calcium ion binding	molecular function	IDA[7060561]	50

GO terms by database search (count: 41)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0036148	phosphatidylglycerol acyl-chain remodeling	biological process	TAS	1
GO:0046470	phosphatidylcholine metabolic process	biological process	IDA[7060561]	2
GO:0032052	bile acid binding	molecular function	ISS[7060561]	1
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	ISS[15528384]	91
GO:0006644	phospholipid metabolic process	biological process	TAS	18
GO:0035556	intracellular signal transduction	biological process	ISS[15528384]	38
GO:0030141	secretory granule	cellular component	IEA	14
GO:0015758	glucose transport	biological process	ISS[1918029]	7
GO:0050830	defense response to Gram-positive bacterium	biological process	IDA[12860195]	7
GO:0019731	antibacterial humoral response	biological process	IDA[12860195]	2
GO:0048146	positive regulation of fibroblast proliferation	biological process	IC[1918029]	7
GO:0006633	fatty acid biosynthetic process	biological process	IDA[1918029]	4
GO:0005615	extracellular space	cellular component	IDA[12860195]	85
GO:0045740	positive regulation of DNA replication	biological process	IDA[1918029]	7
GO:0002227	innate immune response in mucosa	biological process	IDA[12860195]	1
GO:0019370	leukotriene biosynthetic process	biological process	ISS[16005851]	3
GO:0050714	positive regulation of protein secretion	biological process	TAS[17981679]	2
GO:0046474	glycerophospholipid biosynthetic process	biological process	TAS	5
GO:0032431	activation of phospholipase A2 activity	biological process	TAS[17981679]	1
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological process	ISS[15528384]	12
GO:0007165	signal transduction	biological process	TAS[9886417]	136
GO:0036152	phosphatidylethanolamine acyl-chain remodeling	biological process	TAS	2
GO:0047498	calcium-dependent phospholipase A2 activity	molecular function	IDA[7060561]	1
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0005576	extracellular region	cellular component	TAS	97
GO:0004623	phospholipase A2 activity	molecular function	IDA[1918029]	3
GO:0007015	actin filament organization	biological process	TAS[9886417]	7
GO:0032637	interleukin-8 production	biological process	ISS[15528384]	1
GO:0009986	cell surface	cellular component	IDA[1918029]	40
GO:0030593	neutrophil chemotaxis	biological process	ISS[16005851]	8
GO:0002446	neutrophil mediated immunity	biological process	ISS[16005851]	4
GO:0050482	arachidonic acid secretion	biological process	TAS[12423354]	8
GO:0050778	positive regulation of immune response	biological process	ISS[16005851]	1
GO:0000187	activation of MAPK activity	biological process	ISS[15528384]	14
GO:0036149	phosphatidylinositol acyl-chain remodeling	biological process	TAS	1
GO:0036151	phosphatidylcholine acyl-chain remodeling	biological process	TAS	2
GO:0044240	multicellular organismal lipid catabolic process	biological process	IDA[7060561]	1
GO:0006654	phosphatidic acid biosynthetic process	biological process	TAS	2
GO:0032869	cellular response to insulin stimulus	biological process	ISS[1918029]	12
GO:0010524	positive regulation of calcium ion transport into cytosol	biological process	ISS[15528384]	3
GO:0036150	phosphatidylserine acyl-chain remodeling	biological process	TAS	1

Gene related KEGG pathways (count: 10)

KEGG pathways by PBA (count: 4)

ID	Name	No. of Genes in BDgene
hsa04730	Long-term depression	15
hsa00591	Linoleic acid metabolism	2
hsa04010	MAPK signaling pathway	39
hsa00590	Arachidonic acid metabolism	7

KEGG pathways by database search (count: 6)

ID	Name	No. of Genes in BDgene
hsa00564	Glycerophospholipid metabolism	7
hsa04664	Fc epsilon RI signaling pathway	13
hsa04370	VEGF signaling pathway	11
hsa00592	alpha-Linolenic acid metabolism	2
hsa00565	Ether lipid metabolism	3
hsa04912	GnRH signaling pathway	17

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PLA2G1B	PLAA	NO	in vitro	2052621
PLA2G1B	BGN	NO	in vitro	9848887
PLA2G1B	PLA2G2A	NO	in vitro	7721806
PLA2G1B	CSF3R	NO	in vitro	14557262

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
PLA2_1-8 allele	duplication		2 (0/2/0)
PLA2G1B_microsatellite polymorphisms	microsatellite		2 (2/0/0)

Gene related regions (count: 6)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
12q24.3	chr12:120300000-133275309	1 (1/0/0)
Chr 12	chr12:0-133275309	3 (0/3/0)
12q24	chr12:108600000-133275309	4 (1/1/2)
12q23-q24	chr12:95800000-133275309	3 (2/0/1)
12q24.31	chr12:120300000-125400000	1 (1/0/0)
12q	chr12:38200000-133851895	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 3)

Reference	ID in SZGene	Result Category
11353443	141	Negative
10551547	141	Negative
15318030	141	Negative

Gene relationship with MDD

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Region: chr12:120322111..120327789 View in gBrowse