Gene Report

Basic Info
Approved Symbol CSNK1D
Symbol Alias HCKID, CKID, CKIdelta
Approved Name casein kinase 1, delta
Location 17q25
Position chr17:82239023-82273731, -1
External Links HGNC: 2452
Entrez Gene: 1453
Ensembl: ENSG00000141551
UCSC: uc002kej.3
No. of Studies 4 (Positive: 2; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 4)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Matsunaga, S.,2012 SNP: rs3829773, rs4789846, rs6502097, rs9901910 None of the SNPs showed a significant association with MDD, but a SNP (rs2075984) in CSNK1E and SNP (rs6502097) in CSNK1D were associated with SCZ (P=0.0091, uncorrected) and BD (P=0.030, uncorrected), respectively. Positive Comment on Study
Byrne, E. M., 2014 P-value=0.60. Gene-based tests show no significant association between this gene and BD. Negative Comment on Study
Kripke, D. F.,2009 SNP: rs4510078 Significant association was observed in the BP group. Positive Comment on Study
Mansour, H. A.,2009 Gene-based tests:X<sup>2</sup>=3.077, P-value = 0.125 in recessive model, X<sup>2</sup>=0.286, P-value = 0.613 in additive model, X<sup>2</sup>=0.001, P-value = 1 in dominant model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 32)

GO terms by PBA (count: 4)

GO terms by database search (count: 28)

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 4)

Gene related interactors from protein-protein interactions data in HPRD (count: 14)

Related other genetic factors
Gene related SNPs (count: 6)

Literature-origin SNPs (count: 5)

LD-proxies (count: 1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 3)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr17:82239023..82273731 View in gBrowse
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