Gene Report

Basic Info
Approved Symbol GPR50
Symbol Alias H9, Mel1c
Approved Name G protein-coupled receptor 50
Location Xq28
Position chrX:151176653-151181465, 1
External Links HGNC: 4506
Entrez Gene: 9248
Ensembl: ENSG00000102195
UCSC: uc010ntg.2
No. of Studies 3 (Positive: 2; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Alaerts, M., 2006 Other variant: GPR50_delta502-505 No significant association was detected in the Northern Swedish association sample. Negative Comment on Study
Thomson, P. A.,2005(b) SNP: rs13440581, rs2072621
Haplotype: (GPR50_502-505) - rs13440581(), rs2072621 - (GPR50_502-505)(), rs2072621 - (GPR50_502-505) - rs13440581(), rs2072621 - rs13440581()
Other variant: GPR50_delta502-505
We have shown that GPR50 is a strong candidate gene for female-associated affective disorder. Positive Comment on Study
Macintyre, D. J.,2010 SNP: rs1202874, rs13440581, rs2072621, rs529386, rs561077
Other variant: GPR50_delta502-505
To our knowledge this is the first association of rs1202874 with BD and is the second positive association at the GPR50 locus. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 7)

GO terms by PBA (count: 1)

GO terms by database search (count: 6)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 5)

Literature-origin SNPs (count: 5)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chrX:151176653..151181465 View in gBrowse
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