Gene Report

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Basic Info

Approved Symbol	CHD1L
Symbol Alias	ALC1
Approved Name	chromodomain helicase DNA binding protein 1-like
Location	1q21.1
Position	chr1:147242641-147295766, 1
External Links	HGNC: 1916 Entrez Gene: 9557 Ensembl: ENSG00000131778 UCSC: uc001epm.5
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Noor A., 2014		Selected stringent CNV related to this gene is validated by qPCR from BD case data.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[19661379]	283
GO:0003677	DNA binding	molecular function	IEA	83
GO:0005886	plasma membrane	cellular component	IDA	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0032508	DNA duplex unwinding	biological process	TAS[19661379]	5
GO:0016887	ATPase activity	molecular function	IMP[19661379]	13
GO:0005515	protein binding	molecular function	IPI[19661379]	563
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0006281	DNA repair	biological process	TAS[19661379]	16
GO:0000166	nucleotide binding	molecular function	IDA[19661379]	17
GO:0004003	ATP-dependent DNA helicase activity	molecular function	TAS[19661379]	3
GO:0006974	cellular response to DNA damage stimulus	biological process	IDA[19661379]	14
GO:0005524	ATP binding	molecular function	IEA	118
GO:0006338	chromatin remodeling	biological process	IDA[19661379]	8
GO:0005737	cytoplasm	cellular component	IDA	322

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Abdul Noor[2014]_1	chr1:144943150-146293282 (NCBI Build 36/hg18)	1	1q21.1	duplication

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p13.2-1q21.3	chr1:111200000-155100000	1 (1/0/0)
1p32.1-q31.1	chr1:58500000-190800000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:147242641..147295766 View in gBrowse