Gene Report

Approved Symbol	MAOA
Approved Name	monoamine oxidase A
Location	Xp11.4-p11.3
Position	chrX:43654907-43746824, 1
External Links	HGNC: 6833 Entrez Gene: 4128 Ensembl: ENSG00000189221 UCSC: uc004dfy.4
No. of Studies	21 (Positive: 10; Negative: 11; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Craddock, N.,1995	Other variant: MAOA_intron 2_dinucleotide repeat, MAOA_intron 1_VNTR, MAOA_exon 8_Fnu4HI Polymorphism	MAOA-RFLP: X<sup>2</sup> = 0.48, df = 1, P-value = 0.49; MAOA-CA: X<sup>2</sup> = 9.56, df = 8, P-value = 0.30; MAOA-VNTR: X<sup>2</sup> = 1.07, df = 2, P-value = 0.59. . No evidence for allelic association was observed between any of the markers and bipolar disorder.	Negative	Comment on Study
Lim, L. C.,1995	Other variant: MAOA_(CA)n, MAOA_VNTR, MAOA_Fnu4HI Polymorphism	For marker MAOA-CA: X<sup>2</sup> = 24.63, Exact P-value < 0.0019; For marker MAOA-VNTR, X<sup>2</sup> = 15.86, df = 4, P-value = 0.0032, and the effect was strongest in females X<sup>2</sup> = 17.96, df = 4, P-value = 0.0013;For marker MAOA-RFLP, X<sup>2</sup> = 8.48, df = 1, P-value = 0.0036, and particularly so for females, X<sup>2</sup> = 8.76, df = 1, P-value = 0.0031; . Our results show evidence for allelic association between bipolar disorder and alleles at 3 MAOA markers	Positive	Comment on Study
Eslami Amirabadi, M. R., 2015	Other variant: MAOA_CA, MAOA_VNTR, MAOA_RFLP	The obtained results confirm some previous studies regarding a gender specific association of MAOA gene with the bipolar disorder.	Positive	Comment on Study
Kawada, Y.,1995		Overall association between the disorder and alleles of the MAOA locus (X<sup>2</sup> = 14.03, df = 6, P-value = 0.029); For A4 allele, the frequencies were higher in patients (X<sup>2</sup> = 4.14, df = 1, P-value = 0.042); For A5 allele, it was opposite (X<sup>2</sup> = 6.31, df = 1, P-value = 0.012).. The differences do not reach the significant level after multiple correction, we suggested a weak but significant overall difference in allele distribution between patients and controls.	Positive	Comment on Study
Fan, M.,2010	Other variant: MAOA_(CA)n, MAOA_T941G, MAOA_promoter_VNTR	Our meta-analysis suggests a significant association of the MAOA gene with major depressive disorder and BPD within specific groups	Positive	Comment on Study
Serretti, A.,2002	Other variant: MAOA_promoter_VNTR	Our study did not support the involvement of 5-HTTLPR, TPH, MAO-A, or DRD4 polymorphisms in bipolar disorder.	Negative	Comment on Study
Gutierrez, B., 2004	Other variant: uMAOA	In female bipolar disorder patients, long alleles were associated with longest times of admission (F=4.604, P-value = 0.037). A trend for association with seasonal pattern was also defined in this group (data not corrected for multiple testing).. Our results suggest that MAOA gene variation may modulate the expression of some clinical aspects of severe mood disorders, especially in females, and support the existence of a genetic and aetiologic heterogeneity underlying the diagnoses of bipolar disorder and major depression.	Positive	Comment on Study
Huang, S. Y.,2008	SNP: rs1137070	Our results suggest that MAOA polymorphisms do not play a major role in pathogenesis of BD or its clinical subtypes in Han Chinese.	Negative	Comment on Study
Muramatsu, T., 1997	Other variant: MAOA_(CA)n, MAOA_exon 8_VNTR, MAOA_exon 8_RFLP	Therefore, our results did not support the involvement of the alleles at MAOA and MAOB in the etiology of mood disorder.	Negative	Comment on Study
Parsian, A., 1997	Other variant: MAOA_1-8 allele	These data do not support the association of MAO-A or B with bipolar affective disorder but do demonstrate that undetected population stratification can be an important source of bias in case-control studies.	Negative	Comment on Study
Sasaki, T., 1998	Other variant: MAOA_T941G, MAOA_A1609G	No evidence for the genetic association between the MAO-A gene and major psychosis was obtained in the Japanese subjects.	Negative	Comment on Study
Muller, D. J., 2007	Haplotype: MAOA_-941T>G - MAOA_-VNTR(T-4), MAOA_-941T>G - MAOA_-VNTR(G-3), MAOA_-941T>G - MAOA_-VNTR(T-3), MAOA_-941T>G - MAOA_-VNTR(G-4), MAOA_-941T>G - MAOA_-VNTR(T-5), MAOA_-941T>G - MAOA_-VNTR(T-3.5), MAOA_-941T>G - MAOA_-VNTR(G-5) Other variant: MAOA_promoter_VNTR, MAOA_T941G	The family-based association study gives mild but further support of the involvement of MAOA variants in bipolar disorder.	Positive	Comment on Study
Hu, M. C.,2012	Other variant: MAOA_promoter_VNTR	The MAOA-uVNTR 3-repeat had a significant protective effect on the ALC+BP (odds ratio=0.432, p=0.035) but not on the healthy controls. However, the interaction between the MAOA-uVNTR 3-repeat and DRD2 A1/A2 was a risk factor in the ALC+BP (odds ratio=3.451, p=0.018). CONCLUSIONS: We indicated the impact of the association between MAOA-uVNTR 3-repeat and DRD2 A1/A2 with ALC+BP.	Positive	Comment on Study
Rubinsztein, D. C.,1996	Other variant: MAOA_RFLP, MAOA_(CA)n	We found a significant difference between the pooled normal and bipolar allele frequencies both for the microsatellite and the RFLP at MAOA.	Positive	Comment on Study
Turecki, G.,1999	Other variant: MAOA_promoter_VNTR	Our results were not supportive of a major role of MAOA in the predisposition to bipolar disorder.	Negative	Comment on Study
Kunugi, H.,1999(b)	Other variant: MAOA_promoter_VNTR	There was no significant genotypic or allelic association, suggesting that the functional VNTR polymorphism in the MAOA gene is unlikely to play a major role in the pathogenesis of bipolar disorder or unipolar depression.	Negative	Comment on Study
Kirov, G.,1999(b)	Other variant: MAOA_promoter_VNTR	No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied.	Negative	Comment on Study
Furlong, R. A.,1999(a)	Other variant: MAOA_(CA)n, MAOA-Fnu	Significant differences were found in Meta analysis.	Positive	Comment on Study
Preisig, M.,2000	Other variant: MAOA_promoter_VNTR, MAOA_RFLP, MAOA_(CA)n	A significant difference in the distribution of the alleles for the MAOA-CA repeat was observed between the female bipolar patients and comparison group.	Positive	Comment on Study
Lin, S.,2000	Other variant: MAOA_(CA)n	As for association studies, no significant association between bipolar disorder and MAOA gene was detected.	Negative	Comment on Study
Syagailo, Y. V.,2001	Other variant: MAOA_LPR	Our results suggest that there is no association between MAOA-LPR genotype and susceptibility to recurrent major depression, bipolar disorder, and schizophrenia in our population.	Negative	Comment on Study

Region: chrX:43654907..43746824 View in gBrowse