Gene Report

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Basic Info

Approved Symbol	CMTM8
Previous Symbol	CKLFSF8
Approved Name	CKLF-like MARVEL transmembrane domain containing 8
Previous Name	chemokine-like factor super family 8, "chemokine-like factor superfamily 8"
Location	3p22.2
Position	chr3:32238679-32370325, 1
External Links	HGNC: 19179 Entrez Gene: 152189 Ensembl: ENSG00000170293 UCSC: uc003cex.3
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BP:Smallest P-value per gene=0.00024, Product of P truncation <=0.01=0.00007, Product of P truncation <=0.001=0.00027. It showed evidence for association with BD.	Positive	Comment on Study
Ollila, H. M.,2009	SNP: rs4276227	It showed no evidence for association with BPI in our study.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005125	cytokine activity	molecular function	IEA	13

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005615	extracellular space	cellular component	IEA	85
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0006935	chemotaxis	biological process	IEA	7

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CMTM8	EGFR	YES	in vivo	16263120

Related other genetic factors

Gene related SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4627791	chr3:32306332 - 32306332(1)	intron_variant	1(0/0/1)
rs4276227	chr3:32289194 - 32289194(1)	intron_variant	3(0/1/2)

rs_ID	Location	Functional Annotation
rs4955275	chr3:32292178 - 32292178(1)	intron_variant
rs1398101	chr3:32304207 - 32304207(1)	intron_variant
rs4484229	chr3:32289317 - 32289317(1)	intron_variant
rs6771770	chr3:32290171 - 32290171(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	It showed no evidence for association with SZ.	Negative

Gene relationship with MDD

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Region: chr3:32238679..32370325 View in gBrowse