Gene Report

Approved Symbol	KCNN3
Symbol Alias	KCa2.3, hSK3, SKCA3
Approved Name	potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
Previous Name	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Name Alias	small conductance calcium-activated potassium channel 3
Location	1q21.3
Position	chr1:154697455-154870280, -1
External Links	HGNC: 6292 Entrez Gene: 3782 Ensembl: ENSG00000143603 UCSC: uc001ffp.3
No. of Studies	7 (Positive: 1; Negative: 6; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Koefoed, P.,2011	SNP: rs884664	KCNN3_rs884664=2 (two indicate homozygosity for the minor allele) occurred in 45 3-combinations.In 1000 permutation tests, at least one cluster of this type (with at least 37 pseudo-patients) were seen 42 times (p=0.042), two such clusters were seen 3 times (p=0.003), and at least three or more clusters of this type did not occur once(p<0.001).. The present analyses of the combinations of SNP genotypes support a role for both genetic heterogeneity and interactions in the genetic architecture of bipolar disorder.	Positive	Comment on Study
Jin, D. K.,2001	Other variant: KCNN3_exon 1_CAG-repeat	A longer CAG repeat alleles of KCNN3 or CTG 18.1 may not be a risk factor for BPAD in Korean population.	Negative	Comment on Study
Ujike, H.,2001	Other variant: KCNN3_exon 1_CAG-repeat	There were no significant differences in the CAG repeat number of longer or shorter alleles among the four diagnostic groups or among the schizophrenia hebephrenic and paranoid subtypes.	Negative	Comment on Study
Saleem, Q.,2000	Other variant: KCNN3_exon 1_CAG-repeat	There was no significant difference in the distributions of difference in allele sizes between controls and both patient groups.	Negative	Comment on Study
Meira-Lima, I. V.,2001	Other variant: KCNN3_CAG/CTG repeat	Our data do not support the hypothesis that variation at the polymorphic CAG/CTG repeat loci KCNN3 influence susceptibility to BPAD in our sample.	Negative	Comment on Study
Glatt, S. J.,2003	Other variant: KCNN3_exon 1_CAG-repeat	The results of these meta-analyses demonstrate that the risks for both schizophrenia and bipolar disorder are largely, if not entirely, independent of CAG-repeat length in exon 1 of KCNN3.	Negative	Comment on Study
Guy, C. A.,1999	Other variant: hKCa_CAG repeat	We conclude that our data provide no support for the hypothesis that variation at the hKCa3 gene contributes to susceptibility to bipolar disorder.	Negative	Comment on Study

Region: chr1:154697455..154870280 View in gBrowse