Gene Report

Basic Info
Approved Symbol KCNN3
Symbol Alias KCa2.3, hSK3, SKCA3
Approved Name potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
Previous Name potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Name Alias small conductance calcium-activated potassium channel 3
Location 1q21.3
Position chr1:154697455-154870280, -1
External Links HGNC: 6292
Entrez Gene: 3782
Ensembl: ENSG00000143603
UCSC: uc001ffp.3
No. of Studies 7 (Positive: 1; Negative: 6; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 7)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Koefoed, P.,2011 SNP: rs884664 KCNN3_rs884664=2 (two indicate homozygosity for the minor allele) occurred in 45 3-combinations.In 1000 permutation tests, at least one cluster of this type (with at least 37 pseudo-patients) were seen 42 times (p=0.042), two such clusters were seen 3 times (p=0.003), and at least three or more clusters of this type did not occur once(p<0.001).. The present analyses of the combinations of SNP genotypes support a role for both genetic heterogeneity and interactions in the genetic architecture of bipolar disorder. Positive Comment on Study
Jin, D. K.,2001 Other variant: KCNN3_exon 1_CAG-repeat A longer CAG repeat alleles of KCNN3 or CTG 18.1 may not be a risk factor for BPAD in Korean population. Negative Comment on Study
Ujike, H.,2001 Other variant: KCNN3_exon 1_CAG-repeat There were no significant differences in the CAG repeat number of longer or shorter alleles among the four diagnostic groups or among the schizophrenia hebephrenic and paranoid subtypes. Negative Comment on Study
Saleem, Q.,2000 Other variant: KCNN3_exon 1_CAG-repeat There was no significant difference in the distributions of difference in allele sizes between controls and both patient groups. Negative Comment on Study
Meira-Lima, I. V.,2001 Other variant: KCNN3_CAG/CTG repeat Our data do not support the hypothesis that variation at the polymorphic CAG/CTG repeat loci KCNN3 influence susceptibility to BPAD in our sample. Negative Comment on Study
Glatt, S. J.,2003 Other variant: KCNN3_exon 1_CAG-repeat The results of these meta-analyses demonstrate that the risks for both schizophrenia and bipolar disorder are largely, if not entirely, independent of CAG-repeat length in exon 1 of KCNN3. Negative Comment on Study
Guy, C. A.,1999 Other variant: hKCa_CAG repeat We conclude that our data provide no support for the hypothesis that variation at the hKCa3 gene contributes to susceptibility to bipolar disorder. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 8)

GO terms by PBA (count: 4)

GO terms by database search (count: 4)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 2)

Literature-origin SNPs (count: 1)

LD-proxies (count: 1)

Gene related CNVs (count: 0)

Gene related other variants (count: 3)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 3)

Overlap with SZ from candidate gene intersection analysis (count: 23)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr1:154697455..154870280 View in gBrowse
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