Gene Report

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Basic Info

Approved Symbol	WDR1
Approved Name	WD repeat domain 1
Location	4p16.1
Position	chr4:10074339-10116949, -1
External Links	HGNC: 12754 Entrez Gene: 9948 Ensembl: ENSG00000071127 UCSC: uc032tce.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Le Hellard, S., 2007		We examined the 48 SNPs in the significant shared region and thirteen are in WDR1, a WD repeat domain protein. Description of a 200-kb region of increased allele sharing prioritizes this region, which contains two functional candidate genes for BPAD, SLC2A9, and WDR1, for subsequent studies.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003779	actin binding	molecular function	IEA	24

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0002102	podosome	cellular component	IEA	3
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0007605	sensory perception of sound	biological process	TAS[10036186]	18
GO:0005884	actin filament	cellular component	IEA	9
GO:0030054	cell junction	cellular component	IEA	88
GO:0002576	platelet degranulation	biological process	TAS	5
GO:0007596	blood coagulation	biological process	TAS	44
GO:0030168	platelet activation	biological process	TAS	22
GO:0042995	cell projection	cellular component	IEA	9
GO:0005829	cytosol	cellular component	TAS	223
GO:0048713	regulation of oligodendrocyte differentiation	biological process	IEA	2
GO:0005576	extracellular region	cellular component	TAS	97
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
WDR1	CARD11	NO	in vivo	17293856
WDR1	CFL1	NO	in vitro;yeast 2-hybrid	10366597
WDR1	SKIV2L	YES	yeast 2-hybrid	15231747

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 4	chr4:0-190214555	3 (0/3/0)
4p16.1	chr4:6000000-11300000	2 (0/2/0)
4p16	chr4:0-11300000	2 (0/1/1)
4p	chr4:0-50000000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr4:10074339..10116949 View in gBrowse