Gene Report

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Basic Info

Approved Symbol	TMEM108
Symbol Alias	MGC3040, CT124
Approved Name	transmembrane protein 108
Name Alias	cancer/testis antigen 124
Location	3q22.1
Position	chr3:133038391-133397792, 1
External Links	HGNC: 28451 Entrez Gene: 66000 Ensembl: ENSG00000144868 UCSC: uc003epi.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BD:Smallest P-value per gene=0.04004, Product of P truncation <=0.01=0.00735, Product of P truncation <=0.001=NA. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003674	molecular_function	molecular function	ND	24
GO:0005575	cellular_component	cellular component	ND	19
GO:0008150	biological_process	biological process	ND	24

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3q22.1-q25.31	chr3:129500000-157300000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	In SZ:Smallest P-value per gene=0.00038, Product of P truncation <=0.01=0.00006, Product of P truncation <=0.001=0.00007 It showed evidence for association with SZ.	Positive

Reference	ID in SZGene	Result Category
18677311	738	Positive

Gene relationship with MDD

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Region: chr3:133038391..133397792 View in gBrowse