Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	FZD2
Approved Name	frizzled class receptor 2
Previous Name	frizzled (Drosophila) homolog 2, "frizzled homolog 2 (Drosophila)", "frizzled 2, seven transmembrane spanning receptor", "frizzled family receptor 2"
Location	17q21.1
Position	chr17:44557459-44559570, 1
External Links	HGNC: 4040 Entrez Gene: 2535 Ensembl: ENSG00000180340 UCSC: uc002igx.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Ollila, H. M.,2009	SNP: rs4792948	It showed no evidence for association with BPI in our study.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 27)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IDA[18929644]; TAS	360
GO:0016021	integral component of membrane	cellular component	IBA	219
GO:0030165	PDZ domain binding	molecular function	IPI[19388021]	16

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IDA[18215320]	58
GO:0060119	inner ear receptor cell development	biological process	IEA	4
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	biological process	IDA[18929644]	11
GO:0005925	focal adhesion	cellular component	IDA[21423176]	32
GO:0060070	canonical Wnt signaling pathway	biological process	IDA[18215320]	9
GO:0003151	outflow tract morphogenesis	biological process	IEA	4
GO:0090103	cochlea morphogenesis	biological process	IEA	3
GO:0090263	positive regulation of canonical Wnt signaling pathway	biological process	TAS	9
GO:0003149	membranous septum morphogenesis	biological process	IEA	2
GO:0003150	muscular septum morphogenesis	biological process	IEA	1
GO:0060022	hard palate development	biological process	IEA	2
GO:0004930	G-protein coupled receptor activity	molecular function	IBA	26
GO:0030855	epithelial cell differentiation	biological process	IEA	5
GO:0030669	clathrin-coated endocytic vesicle membrane	cellular component	TAS	4
GO:0042813	Wnt-activated receptor activity	molecular function	IBA	2
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IEA	64
GO:0005737	cytoplasm	cellular component	IDA[19038973]	322
GO:0007608	sensory perception of smell	biological process	IEA	8
GO:0030825	positive regulation of cGMP metabolic process	biological process	IMP[19946729]	1
GO:0017147	Wnt-protein binding	molecular function	IBA	5
GO:0035567	non-canonical Wnt signaling pathway	biological process	IBA	2
GO:0090179	planar cell polarity pathway involved in neural tube closure	biological process	IEA	1
GO:0007267	cell-cell signaling	biological process	IEA	29
GO:0030182	neuron differentiation	biological process	ISS	5

Gene related KEGG pathways (count: 4)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa05217	Basal cell carcinoma	8

KEGG pathways by database search (count: 3)

ID	Name	No. of Genes in BDgene
hsa05210	Colorectal cancer	14
hsa04310	Wnt signaling pathway	20
hsa04916	Melanogenesis	16

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
FZD2	DLG4	NO	yeast 2-hybrid	12067714

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4792948	chr17:44560120 - 44560120(1)	downstream_gene_variant	1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
17p12-q21.33	chr17:10800000-52100000	1 (0/1/0)
17q21	chr17:39800000-52100000	1 (0/1/0)
17q11-q23	chr17:25100000-64600000	1 (0/1/0)
17q11-25	chr17:25100000-83257441	1 (1/0/0)
Chr 17	chr17:0-83257441	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr17:44557459..44559570 View in gBrowse