Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	MAGI2
Symbol Alias	AIP1, ARIP1, KIAA0705, ACVRIP1, MAGI-2
Approved Name	membrane associated guanylate kinase, WW and PDZ domain containing 2
Location	7q21
Position	chr7:78017057-79453574, -1
External Links	HGNC: 18957 Entrez Gene: 9863 Ensembl: ENSG00000187391 UCSC: uc003ugx.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, X., 2015	SNP: rs3823786	MAGI2 has been reported to be related to SCZ, BPD, depressive syndrome, alcohol dependence, antidepressive agents and hippocampal atrophy.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 34)

GO terms by PBA (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IDA[10760291]	360
GO:0045202	synapse	cellular component	ISS	29
GO:0005634	nucleus	cellular component	IDA[10760291]	283
GO:0004871	signal transducer activity	molecular function	IEA	32

GO terms by database search (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043234	protein complex	cellular component	ISS	27
GO:0003402	planar cell polarity pathway involved in axis elongation	biological process	NAS[20534871]	1
GO:0005737	cytoplasm	cellular component	IDA[11526121]	322
GO:0002092	positive regulation of receptor internalization	biological process	IDA[11526121]	4
GO:0048471	perinuclear region of cytoplasm	cellular component	ISS	50
GO:0010976	positive regulation of neuron projection development	biological process	ISS	10
GO:0038180	nerve growth factor signaling pathway	biological process	ISS	2
GO:0005923	tight junction	cellular component	IDA[10760291]	13
GO:0036057	slit diaphragm	cellular component	ISS	1
GO:0060395	SMAD protein signal transduction	biological process	ISS	4
GO:0005770	late endosome	cellular component	ISS	4
GO:0030425	dendrite	cellular component	ISS	65
GO:0008285	negative regulation of cell proliferation	biological process	ISS	41
GO:0019902	phosphatase binding	molecular function	IPI[10760291]	9
GO:0030336	negative regulation of cell migration	biological process	ISS	12
GO:0072015	glomerular visceral epithelial cell development	biological process	ISS	1
GO:0032926	negative regulation of activin receptor signaling pathway	biological process	ISS	2
GO:0016482	cytoplasmic transport	biological process	ISS	1
GO:0031697	beta-1 adrenergic receptor binding	molecular function	IPI[11526121]	1
GO:0032516	positive regulation of phosphoprotein phosphatase activity	biological process	IDA[10760291]	1
GO:0043113	receptor clustering	biological process	ISS	8
GO:0030159	receptor signaling complex scaffold activity	molecular function	IDA[11526121]	3
GO:0051898	negative regulation of protein kinase B signaling	biological process	IDA[10760291]	6
GO:0071850	mitotic cell cycle arrest	biological process	ISS	1
GO:0046332	SMAD binding	molecular function	ISS	2
GO:0070699	type II activin receptor binding	molecular function	ISS	1
GO:0005515	protein binding	molecular function	IPI[10548487]	563
GO:1990090	cellular response to nerve growth factor stimulus	biological process	ISS	4
GO:0014069	postsynaptic density	cellular component	ISS	26
GO:0051291	protein heterooligomerization	biological process	ISS	8

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04530	Tight junction	18

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa05050	Dentatorubropallidoluysian atrophy (DRPLA)	4

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 12)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
MAGI2	DSCAML1	NO	yeast 2-hybrid	12421765
MAGI2	ADRB1	NO	in vitro;in vivo;yeast 2-hybrid	11526121
MAGI2	GRID2	NO	in vivo;yeast 2-hybrid	12589829
MAGI2	PTEN	NO	in vivo;yeast 2-hybrid	10760291
MAGI2	DLL1	NO	in vitro;yeast 2-hybrid	14529612
MAGI2	SMAD3	NO	in vitro;in vivo	10681527
MAGI2	TGFA	NO	in vitro;yeast 2-hybrid	15652357
MAGI2	PLXNB3	NO	yeast 2-hybrid	12421765
MAGI2	CTNNB1	NO	in vivo	11826105
MAGI2	ACVR2A	NO	in vitro;yeast 2-hybrid	10681527
MAGI2	RAPGEF2	NO	in vitro;in vivo	10548487
MAGI2	ATN1	NO	in vitro;yeast 2-hybrid	9647693

Related other genetic factors

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3823786	chr7:78151898 - 78151898(1)	intron_variant; NMD_transcript_variant	1(1/0/0)

LD-proxies (count: 1)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs13438107		chr7:78123917 - 78123917(1)	intron_variant; NMD_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q21	chr7:77900000-98400000	4 (0/2/2)
7q21-31	chr7:77900000-127500000	1 (1/0/0)
Chr 7	chr7:0-159345973	3 (0/3/0)
7p15-q21	chr7:20900000-98400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:78017057..79453574 View in gBrowse