Gene Report

Basic Info
Approved Symbol VAMP2
Previous Symbol SYB2
Symbol Alias VAMP-2
Approved Name vesicle-associated membrane protein 2 (synaptobrevin 2)
Location 17p13.1
Position chr17:8159149-8163546, -1
External Links HGNC: 12643
Entrez Gene: 6844
Ensembl: ENSG00000220205
UCSC: uc010cnt.1
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Abou Jamra, R, 2008 (b) SNP: rs2278637, rs8067606
Haplotype: rs2278637 - rs8067606()
Other variant: VAMP2_C_25610873_10
We could not replicate our initial finding in the single-marker analysis. Our results do not suggest that a common genetic variant at VAMP2 contributes to the development of BD in German patients. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 65)

GO terms by PBA (count: 6)

GO terms by database search (count: 59)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 15)

Related other genetic factors
Gene related SNPs (count: 6)

Literature-origin SNPs (count: 2)

LD-proxies (count: 4)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr17:8159149..8163546 View in gBrowse
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