Gene Report

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Basic Info

Approved Symbol	ST3GAL1
Previous Symbol	SIAT4A
Symbol Alias	ST3O, SIATFL, ST3GalA.1
Approved Name	ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Previous Name	sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase)
Name Alias	ST3Gal I
Location	8q24.22
Position	chr8:133454848-133571940, -1
External Links	HGNC: 10862 Entrez Gene: 6482 Ensembl: ENSG00000008513 UCSC: uc003yuk.2
No. of Studies	4 (Positive: 3; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 4)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Zandi, P. P., 2008 (b)	SNP: rs6986303 Haplotype: rs1411187 - rs6986303()	None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our threshold for study-wide significance (P<3.00E-05). However, there was consistent evidence at our threshold for the suggestive level (P<7.00E-04) from both the single locus and multi-locus tests of associations with SNPs in the genes ADCY8, ST3GAL1, and NSE2.	Positive	Comment on Study
Perlis, 2008	SNP: rs1554324, rs2978012, rs3758105, rs7835464, rs9643297	permuted P< .005 in gene-based association tests. No genes specifically chosen to probe the action of lithium were associated with bipolar disorder. However, gene-based analysis of sialyltransferase 4A (SIAT4A), tachykinin receptor 1 (TACR1), and -aminobutyric acidA 2 receptor subunit (GABRB2) yielded evidence of association.	Positive	Comment on Study
Zandi, P. P., 2007	SNP: rs1457466, rs1870126, rs2945733, rs2978041, rs4377991, rs765847, rs939024 Haplotype: rs1457485 - rs4377991 - rs1870126 - rs765847(), rs2945733 - rs2978033 - rs1554325()	Both the single SNP analysis and the haplotype analysis indicated its association with BP.	Positive	Comment on Study
Zhang, P.,2010	SNP: rs6986303	Our association results showed suggestive evidence of association of BP with loci near ST3GAL1.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016020	membrane	cellular component	IDA[19946888]	137

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	biological process	TAS	4
GO:0000139	Golgi membrane	cellular component	TAS	36
GO:0006054	N-acetylneuraminate metabolic process	biological process	ISS	1
GO:0018146	keratan sulfate biosynthetic process	biological process	TAS	2
GO:0018279	protein N-linked glycosylation via asparagine	biological process	TAS	5
GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	molecular function	IDA[14722111]; ISS	1
GO:0043687	post-translational protein modification	biological process	TAS	9
GO:0006493	protein O-linked glycosylation	biological process	TAS	6
GO:0006468	protein phosphorylation	biological process	IEA	42
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0005975	carbohydrate metabolic process	biological process	TAS	12
GO:0030173	integral component of Golgi membrane	cellular component	IEA	3
GO:0097503	sialylation	biological process	ISS	2
GO:0006464	cellular protein modification process	biological process	TAS[10504389]	7
GO:0009405	pathogenesis	biological process	TAS	13
GO:0044267	cellular protein metabolic process	biological process	TAS	28
GO:0030203	glycosaminoglycan metabolic process	biological process	TAS	5
GO:0032580	Golgi cisterna membrane	cellular component	IEA	2
GO:0006487	protein N-linked glycosylation	biological process	ISS	1
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19199708]	176
GO:0042339	keratan sulfate metabolic process	biological process	TAS	2
GO:0016266	O-glycan processing	biological process	TAS	4

Gene related KEGG pathways (count: 6)

ID	Name	No. of Genes in BDgene	Brief Description
hsa01030	Glycan structures - biosynthesis 1	8

ID	Name	No. of Genes in BDgene
hsa00533	Keratan sulfate biosynthesis	1
hsa00512	O-Glycan biosynthesis	2
hsa01031	Glycan structures - biosynthesis 2	3
hsa00603	Glycosphingolipid biosynthesis - globoseries	2
hsa00604	Glycosphingolipid biosynthesis - ganglioseries	1

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 19)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2945733	chr8:133603507 - 133603507(1)		1(1/0/0)
rs6986303	chr8:133466286 - 133466286(1)	intron_variant; non_coding_transcript_variant	2(1/0/1)
rs4377991	chr8:134067428 - 134067428(1)		1(1/0/0)
rs1457466	chr8:134104396 - 134104396(1)		1(1/0/0)
rs3758105	chr8:133547090 - 133547090(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)
rs1870126	chr8:134081458 - 134081458(1)		1(1/0/0)
rs9643297	chr8:133471452 - 133471452(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant	1(1/0/0)
rs939024	chr8:133574470 - 133574470(1)	downstream_gene_variant; upstream_gene_variant	1(1/0/0)
rs1554324	chr8:133574943 - 133574943(1)	downstream_gene_variant; upstream_gene_variant	1(1/0/0)
rs765847	chr8:134123765 - 134123765(1)		1(1/0/0)
rs7835464	chr8:133472584 - 133472584(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant	1(1/0/0)
rs2978041	chr8:133594434 - 133594434(1)		1(1/0/0)
rs2978012	chr8:133526953 - 133526953(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs9694865	chr8:133555308 - 133555308(1)	intron_variant; non_coding_transcript_variant
rs6471131	chr8:133539163 - 133539163(1)	intron_variant; non_coding_transcript_variant
rs12549002	chr8:133544431 - 133544431(1)	intron_variant; non_coding_transcript_variant
rs2945779	chr8:133529299 - 133529299(1)	intron_variant; non_coding_transcript_variant
rs2978015	chr8:133527636 - 133527636(1)	intron_variant; non_coding_transcript_variant
rs2978014	chr8:133527393 - 133527393(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8q24.13-q24.3	chr8:121500000-145138636	1 (1/0/0)
8q24.21-qter	chr8:126300000-145138636	1 (0/1/0)
Chr 8	chr8:0-145138636	3 (0/3/0)
8q24	chr8:116700000-145138636	7 (2/2/3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr8:133454848..133571940 View in gBrowse