Gene Report

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Basic Info

Approved Symbol	MALL
Symbol Alias	BENE
Approved Name	mal, T-cell differentiation protein-like
Location	2q13
Position	chr2:110083870-110116566, -1
External Links	HGNC: 6818 Entrez Gene: 7851 Ensembl: ENSG00000144063 UCSC: uc002tfk.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs737182	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005886	plasma membrane	cellular component	IDA[11294831]	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045121	membrane raft	cellular component	IDA[11294831]	22
GO:0016023	cytoplasmic membrane-bounded vesicle	cellular component	IDA[11294831]	16
GO:0005515	protein binding	molecular function	IPI[11294831]	563
GO:0042632	cholesterol homeostasis	biological process	NAS[11294831]	8
GO:0030136	clathrin-coated vesicle	cellular component	IDA[11294831]	9
GO:0000139	Golgi membrane	cellular component	IDA[11294831]	36

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
MALL	CAV1	NO	in vitro;in vivo	1294831
MALL	CAV2	NO	in vitro;in vivo	11294831
MALL	CREB3	NO	yeast 2-hybrid	16189514

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs737182	chr2:110105777 - 110105777(1)	intron_variant; NMD_transcript_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q12.3-q22.1	chr2:106700000-141500000	1 (0/1/0)
2p13	chr2:108700000-112200000	2 (2/0/0)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p11-q14	chr2:83100000-129100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:110083870..110116566 View in gBrowse